Ohshima M, Momiyama T, Souda S, Kuratani T, Toda K, Hiasa Y
Department of Pathology, Nissei Hospital, Osaka, Japan.
Pathol Int. 1994 Aug;44(8):645-51. doi: 10.1111/j.1440-1827.1994.tb01725.x.
A 52 year old man presented with primary thyroid plasmacytoma. The patient was initially followed up for thyroid dysfunction. The histological examination of the removed thyroid revealed a proliferation of mature and immature plasma cells indicative of plasmacytoma with Hashimoto's disease. After radiotherapy (40 Gy) to the neck following right hemi-thyroidectomy, the patient is currently alive and well 3 years after diagnosis without any evidence of tumor. The immunohistological examination of the removed thyroid showed monoclonality for immunoglobulin G-Kappa light chains. Sixty-six literature cases of primary thyroid plasmacytoma were reviewed and comparison of the clinical and histological characteristics between Japanese and Western cases noted. The incidence of the patients with antithyroid antibody was significantly lower (P < 0.01) in Western patients (42.9%) than in Japanese patients (87.5%). The higher incidence of thyroid dysfunction and Hashimoto's disease in Japan in comparison with Western nations was well reflected in the incidence of antithyroid antibody.
一名52岁男性被诊断为原发性甲状腺浆细胞瘤。患者最初因甲状腺功能障碍接受随访。切除甲状腺的组织学检查显示，成熟和未成熟浆细胞增生，提示为伴有桥本氏病的浆细胞瘤。在右半甲状腺切除术后对颈部进行放射治疗（40 Gy）后，患者在诊断后3年仍然健在，没有任何肿瘤迹象。切除甲状腺的免疫组织学检查显示免疫球蛋白G-κ轻链呈单克隆性。回顾了66例原发性甲状腺浆细胞瘤的文献病例，并比较了日本和西方病例的临床和组织学特征。西方患者（42.9%）抗甲状腺抗体患者的发生率显著低于日本患者（87.5%）（P < 0.01）。抗甲状腺抗体的发生率很好地反映了日本与西方国家相比甲状腺功能障碍和桥本氏病的较高发生率。
