Yashiro T, Aiba M, Obara T, Fujimoto Y, Hirayama A
Department of Endocrine Surgery, Tokyo Women's Medical College, Japan.
Acta Pathol Jpn. 1988 Mar;38(3):371-81. doi: 10.1111/j.1440-1827.1988.tb02309.x.
A case of primary plasmacytoma of the thyroid gland which occurred in a 63-year-old woman is reported. Histologic and ultramicroscopic examination revealed that the excised thyroid tumor was plasmacytoma superimposed on lymphocytic thyroiditis. Immunohistological study showed that the tumor cells produced intracytoplasmic immunoglobulin (IgG-kappa). Electrophoretic and immunoelectrophoretic studies disclosed the presence of monoclonal immunoglobulin (IgG-kappa) in samples of the patient's serum which had been obtained preoperatively. After completion of irradiation therapy to the neck following tumor removal, the serum monoclonal immunoglobulin disappeared. The patient is currently alive and well without any evidence of the tumor three years after surgery.
报告了一例发生在一名63岁女性身上的甲状腺原发性浆细胞瘤。组织学和超微结构检查显示，切除的甲状腺肿瘤是叠加在淋巴细胞性甲状腺炎上的浆细胞瘤。免疫组织学研究表明，肿瘤细胞产生胞浆内免疫球蛋白（IgG-κ）。电泳和免疫电泳研究显示，在术前采集的患者血清样本中存在单克隆免疫球蛋白（IgG-κ）。肿瘤切除后完成颈部放射治疗后，血清单克隆免疫球蛋白消失。患者目前健在，术后三年无任何肿瘤迹象。
