Titgemeyer F, Reizer J, Reizer A, Saier M H
Department of Biology, University of California at San Diego, La Jolla, CA 92093-0116.
Microbiology (Reading). 1994 Sep;140 ( Pt 9):2349-54. doi: 10.1099/13500872-140-9-2349.
We have characterized a new family of proteins (the ROK family) which includes six transcriptional repressors for sugar catabolic operons, three sugar kinases, and three unidentified open reading frames. Analysis of the aligned sequences and phylogenetic tree construction allow predictions regarding the functional nature of conserved domains and residues within these proteins as well as the pathway of evolutionary divergence that gave rise to the family.
我们已鉴定出一个新的蛋白质家族（ROK家族），其中包括六个糖分解代谢操纵子的转录阻遏物、三个糖激酶以及三个未鉴定的开放阅读框。对排列好的序列进行分析并构建系统发育树，有助于预测这些蛋白质中保守结构域和残基的功能性质，以及产生该家族的进化分歧途径。
