López-Barea F, Rodríguez-Peralto J L, Burgos E, González-López J
Department of Anatomical Pathology La Paz Hospital, Madrid, Spain.
Virchows Arch. 1994;425(2):217-20. doi: 10.1007/BF00230360.
This report illustrates a calcified leiomyoma of deep soft tissue in the left leg of a 6-year-old boy. The tumour was composed of spindle cells arranged in interlacing bundles, between which were multiple small and large areas of calcification. Tumour cells were positive for vimentin, desmin and smooth muscle actin. Ultrastructurally, the cells showed numerous pinocytotic vesicles and bundles of intracytoplasmic filaments with smooth muscle dense bodies. Only four calcified leiomyomas have been previously reported in the deep soft tissues of limbs. Here we report a new case and suggest a new pathogenetic scheme involving alkaline phosphatase in the origin of these calcifications.
本报告展示了一名6岁男孩左腿深部软组织的钙化平滑肌瘤。肿瘤由排列成交错束状的梭形细胞组成，其间有多个大小不一的钙化区域。肿瘤细胞波形蛋白、结蛋白和平滑肌肌动蛋白呈阳性。超微结构上，细胞显示出大量吞饮小泡和带有平滑肌致密小体的胞质内细丝束。此前仅有4例肢体深部软组织钙化平滑肌瘤的报道。在此我们报告1例新病例，并提出一种涉及碱性磷酸酶在这些钙化起源中的新发病机制。
