Heringa J
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Comput Chem. 1994 Sep;18(3):233-43. doi: 10.1016/0097-8485(94)85018-6.
Many proteins sequences contain motifs which display similarity. The similarities between the repeats are a result of gene duplication and/or gene fusion. The evolutionary role of repeats within protein sequences is considered and some repeat examples are given ranging from tandem repeats to multiple types of repeats which are sequentially interspersed. Existing computer methods to delineate repeats in individual protein sequences are discussed and a novel sensitive repeat recognition method is introduced.
许多蛋白质序列包含具有相似性的基序。重复序列之间的相似性是基因复制和/或基因融合的结果。文中考虑了蛋白质序列中重复序列的进化作用，并给出了一些重复序列的例子，从串联重复到多种类型的顺序散布的重复序列。讨论了现有的用于在单个蛋白质序列中描绘重复序列的计算机方法，并介绍了一种新型的灵敏的重复序列识别方法。
