Davis J B, Maher P
Salk Institute for Biological Research, La Jolla, CA 92037.
Brain Res. 1994 Jul 25;652(1):169-73. doi: 10.1016/0006-8993(94)90334-4.
A neuronal cell line, HT-22, is sensitive to glutamate cytotoxicity via a non-receptor mediated oxidative pathway. 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, blocks this glutamate-induced cell death. Down-regulation of protein kinase C eliminates the protection against glutamate cytotoxicity afforded by TPA. The data suggest that protein kinase C activation blocks an early step in the cytotoxic pathway.
一种神经元细胞系HT-22，通过非受体介导的氧化途径对谷氨酸细胞毒性敏感。蛋白激酶C的激活剂十四酰佛波醇乙酯（TPA）可阻断这种谷氨酸诱导的细胞死亡。蛋白激酶C的下调消除了TPA对谷氨酸细胞毒性的保护作用。这些数据表明，蛋白激酶C的激活阻断了细胞毒性途径中的早期步骤。
