Prescher G, Bornfeld N, Becher R
Innere Klinik und Poliklinik (Tumorforschung), Universität Essen, Germany.
Cancer Genet Cytogenet. 1994 Oct 15;77(2):144-6. doi: 10.1016/0165-4608(94)90230-5.
Monosomy 3 and multiplication of 8q are nonrandom findings in uveal melanoma. We present a case in which two subclones could be detected. Both had monosomy 3 in common. Furthermore, a multiplication of chromosome 8 material was also seen in both subclones. However, it was based on different kinds of aberrations and was accompanied by further anomalies, such as loss of a Y-chromosome, an additional chromosome 7, and an additional marker chromosome, in only one clone. This finding allows some insight into the relevance of the most frequently found anomalies of chromosome 3 and 8 in uveal melanoma. As monosomy 3 occurred before any subclone differentiation, it must be an early, if not primary, event in the genesis of this tumor. Multiplication of chromosome 8, specifically of 8q, however, may contribute to the clonal evolution of this tumor.
3号染色体单体和8q倍增是葡萄膜黑色素瘤的非随机发现。我们报告了一例可检测到两个亚克隆的病例。两者都有3号染色体单体。此外，在两个亚克隆中也都观察到8号染色体物质的倍增。然而，它基于不同类型的畸变，并且仅在一个克隆中伴有进一步的异常，如Y染色体缺失、额外的一条7号染色体和一条额外的标记染色体。这一发现有助于深入了解葡萄膜黑色素瘤中最常见的3号和8号染色体异常的相关性。由于3号染色体单体发生在任何亚克隆分化之前，它必定是该肿瘤发生过程中的一个早期（即便不是原发）事件。然而，8号染色体的倍增，特别是8q的倍增，可能促成了该肿瘤的克隆进化。
