Sisley K, Cottam D W, Rennie I G, Parsons M A, Potter A M, Potter C W, Rees R C
Department of Experimental and Clinical Microbiology, Sheffield University, Medical School, United Kingdom.
Genes Chromosomes Cancer. 1992 Oct;5(3):197-200. doi: 10.1002/gcc.2870050304.
We present ten cases of posterior uveal melanoma which were karyotyped after short-term culture. One tumour had a normal chromosome complement. The remaining nine tumours were cytogenetically abnormal, with chromosomes 3, 6, 8, 11, and 13 most frequently involved. Abnormalities of chromosome 13 were seen in two cases, chromosome 11 in three cases, and chromosomes 3, 6, and 8 in five cases. Four tumours, all derived from the ciliary body, demonstrated monosomy 3 and i(8q), confirming the involvement of these aberrations with a subgroup of uveal melanomas arising from the ciliary body.
我们呈现了10例短期培养后进行核型分析的后葡萄膜黑色素瘤病例。其中1例肿瘤具有正常的染色体组。其余9例肿瘤存在细胞遗传学异常，3号、6号、8号、11号和13号染色体受累最为频繁。13号染色体异常见于2例，11号染色体异常见于3例，3号、6号和8号染色体异常见于5例。4例均起源于睫状体的肿瘤表现为3号染色体单体性和i(8q)，证实了这些畸变与起源于睫状体的葡萄膜黑色素瘤亚组有关。
