Schneider B
Arzneimittelforschung. 1976;26(8):1606-10.
In the years 1971 to 1973 the therapeutic effect of Trasylol (aprotinin isolated from bovine organs) in the treatment of the traumatic shock was investigated in a controlled field study at 31 hospitals in northern Germany. The study included 4686 patients. There could be proved a significant reduction in letality by Trasylol treatment even under the broad conditions of general field application. The therapeutic activity of Trasylol was most efficient when Trasylol was applied within 30 min after the trauma and consists especially of a better prognostic for further development. The letality after 12 h is remarkably reduced by an early application of Trasylol and posttraumatic surgical operations have a significantly lower risk.
1971年至1973年期间，在德国北部的31家医院进行了一项对照性实地研究，调查了抑肽酶（从牛器官中分离出的抑肽酶）治疗创伤性休克的疗效。该研究纳入了4686名患者。即使在广泛的一般实地应用条件下，也证明抑肽酶治疗可显著降低死亡率。当在创伤后30分钟内应用抑肽酶时，其治疗活性最为有效，尤其对进一步发展有更好的预后。早期应用抑肽酶可显著降低12小时后的死亡率，创伤后手术的风险也显著降低。
