Shimomura T, Kowa H, Nakano T, Kitano A, Marukawa H, Urakami K, Takahashi K
Division of Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
Cephalalgia. 1994 Jun;14(3):215-8; discussion 181. doi: 10.1046/j.1468-2982.1994.014003215.x.
Superoxide dismutase (SOD) is a radical-scavenging enzyme. We determined Cu, Zn-SOD concentrations and activities in platelets from subjects with migraine and tension-type headaches. Thirty migraine without aura (MWoA) patients, 9 migraine with aura (MWA) patients, and 53 tension-type headache patients were selected for study. Thirty healthy volunteers composed the control group. Concentrations of platelet SOD were determined using enzyme-linked immunosorbent assay techniques. The activity of platelet SOD was determined by measuring reductivity of nitroblue tetrazolium. Low concentrations of platelet SOD were found in patients with MWA and MWoA. Platelet SOD activity decreased in MWA patients but not in patients with MWoA or tension-type headaches. These findings suggest vulnerability to oxidative stress in patients with migraine. It is suggested that low platelet SOD levels may play an important role in the etiology of migraine.
超氧化物歧化酶（SOD）是一种自由基清除酶。我们测定了偏头痛和紧张型头痛患者血小板中铜锌超氧化物歧化酶（Cu, Zn-SOD）的浓度和活性。选取了30例无先兆偏头痛（MWoA）患者、9例有先兆偏头痛（MWA）患者和53例紧张型头痛患者进行研究。30名健康志愿者组成对照组。采用酶联免疫吸附测定技术测定血小板SOD的浓度。通过测量硝基蓝四唑的还原能力来测定血小板SOD的活性。在MWA和MWoA患者中发现血小板SOD浓度较低。MWA患者的血小板SOD活性降低，但MWoA患者或紧张型头痛患者的血小板SOD活性未降低。这些发现表明偏头痛患者易受氧化应激影响。提示血小板SOD水平低可能在偏头痛的病因中起重要作用。
