Bolayir Ertugrul, Celik Kenan, Kugu Nesim, Yilmaz Abdulkerim, Topaktas Suat, Bakir Sevtap
Department of Neurology, Cumhuriyet University, Faculty of Medicine, Sivas, Türkiye.
J Chin Med Assoc. 2004 Jun;67(6):263-7.
The pathophysiology of migraine and other headaches is still unknown, and research is mostly done on neurotransmitter, biochemical and vascular mechanisms. The aim of this study was to examine the role of antioxidant enzymes in the pathophysiology of headache in the interictal period of the pain process.
In this study, glutathione peroxidase, catalase and superoxide dismutase enzyme activities were investigated in 88 cases, which included 11 migraine cases with aura, 17 migraine without aura, 32 chronic type tension headache and 28 control cases.
In migraine cases, superoxide dismutase and glutathione peroxidase enzyme activities were statistically lower than in the tension headache and control groups. The differences between tension-type headache and control groups were found statistically insignificant.
Low intraerythrocytes, superoxide dismutase and glutathione peroxidase levels may play an important role in the etiology of migraine.
偏头痛及其他头痛的病理生理学机制仍不明确，目前的研究主要集中在神经递质、生化及血管机制方面。本研究旨在探讨抗氧化酶在疼痛发作间期头痛病理生理学中的作用。
本研究检测了88例患者的谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶的活性，其中包括11例有先兆偏头痛患者、17例无先兆偏头痛患者、32例慢性紧张型头痛患者和28例对照者。
偏头痛患者的超氧化物歧化酶和谷胱甘肽过氧化物酶活性在统计学上低于紧张型头痛组和对照组。紧张型头痛组与对照组之间的差异无统计学意义。
红细胞内超氧化物歧化酶和谷胱甘肽过氧化物酶水平降低可能在偏头痛的病因学中起重要作用。
