Zuo L F, Qi F Y, Guo J W
Hebei Provincial Cancer Institute, Shijiazhuang.
Zhonghua Bing Li Xue Za Zhi. 1994;23(3):138-40.
The oncogene P21ras expression in premalignant lesions and carcinomas of the stomach was quantitatively studied by flow cytometry and immunofluorescence methods and the relation of P21ras to DNA ploidy and cellular proliferation was analysed. The results showed that P21ras expression was higher in carcinomas than premalignant lesions of the stomach. The fluorescence index in P21ras expression increased with the rise in histological grade. DNA ploidy correlated with the amount of P21ras expression.
采用流式细胞术和免疫荧光法对胃癌癌前病变及癌组织中癌基因P21ras的表达进行了定量研究，并分析了P21ras与DNA倍体及细胞增殖的关系。结果显示，胃癌组织中P21ras的表达高于癌前病变。P21ras表达的荧光指数随组织学分级的升高而增加。DNA倍体与P21ras表达量相关。
