Pellier V, Astic L
Laboratoire de Physiologie Neurosensorielle, Université Claude Bernard/Lyon I, Villeurbanne, France.
Brain Res Dev Brain Res. 1994 Jun 17;79(2):307-15. doi: 10.1016/0165-3806(94)90137-6.
Cell death process in the developing olfactory epithelium was studied by light and electron microscopy in rat embryos from embryonic days 12-18. A massive wave of cell death was observed at embryonic days 12 and 13 and two types of dying cells were seen coexisting. The first type of dying cells exhibited morphological features of apoptosis while the second showed characteristics of a cell death by non-lysosomal disintegration with cytoplasmic swelling and absence of phagocytosis. From embryonic day 14 onward, only apoptotic figures could be still occasionally observed. The significance of such a massive wave of cell death occurring during the earliest developmental stages of the rat olfactory epithelium is discussed in relation with the morphogenesis of the olfactory system.
通过光学显微镜和电子显微镜研究了胚胎第12至18天大鼠胚胎发育中的嗅觉上皮细胞死亡过程。在胚胎第12天和第13天观察到大量细胞死亡浪潮，并且看到两种类型的垂死细胞共存。第一种垂死细胞表现出凋亡的形态特征，而第二种则表现出通过非溶酶体解体导致细胞死亡的特征，伴有细胞质肿胀且无吞噬作用。从胚胎第14天起，仍偶尔能观察到凋亡形态。结合嗅觉系统的形态发生，讨论了大鼠嗅觉上皮最早发育阶段发生如此大规模细胞死亡浪潮的意义。
