Testa V, Capasso G, Maffulli N, Sgambato A, Ames P R
University of Napoli, Medical School, Residency Programme in Orthopaedics, Italy.
Clin Orthop Relat Res. 1994 Nov(308):79-84.
Among other factors, articular cartilage degeneration is caused by proteolytic enzymes. Different cell types of the synovial fluid and/or the synovial membrane and cartilage release specific proteases. Normally, these are finely tuned with their inhibitors. When this balance is altered, the proteolytic action may prevail, producing tissue damage, cartilage disruption, and ultimately a full osteoarthritic picture. The protease antiprotease mechanism opens new perspectives in the diagnosis and pharmacologic management of osteoarthritis. Early diagnosis and improved monitoring of the evolution of the disease are made possible, and a more rational therapy against cartilage disruption becomes feasible.
在其他因素中，关节软骨退变是由蛋白水解酶引起的。滑液和/或滑膜及软骨的不同细胞类型会释放特定的蛋白酶。正常情况下，这些蛋白酶与它们的抑制剂保持着精细的平衡。当这种平衡被打破时，蛋白水解作用可能占主导，导致组织损伤、软骨破坏，最终形成完整的骨关节炎症状。蛋白酶-抗蛋白酶机制为骨关节炎的诊断和药物治疗开辟了新的前景。早期诊断以及对疾病进展的更好监测成为可能，并且针对软骨破坏的更合理治疗也变得可行。
