Miyazaki C, Matsunaga T, Kubo K
Department of Diagnostic Radiology, Sapporo City General Hospital, Hokkaido, Japan.
Clin Nucl Med. 1994 Aug;19(8):689-92. doi: 10.1097/00003072-199408000-00009.
A patient with recently diagnosed severe acute hepatitis underwent serial liver scintigraphy with Tc-99m Sn colloid and Tc-99m DTPA-galactosyl human serum albumin. In initial studies, radionuclide distribution on Tc-99m DTPA-galactosyl human serum albumin scintigraphy was completely discrepant to that on Tc-99m Sn colloid scintigraphy. In a follow-up study 1 month later, the distribution of both radionuclides in the liver appeared relatively homogeneous. The uptake of Tc-99m DTPA-galactosyl human serum albumin and Tc-99m Sn colloid reflects the function of hepatocytes and Kupffer cells, respectively. Both kinds of scintigraphic study may be helpful to assess histopathologic change of different hepatic tissue architectures.
一名近期诊断为严重急性肝炎的患者接受了用锝-99m 锡胶体和锝-99m 二乙三胺五乙酸-半乳糖基人血清白蛋白进行的系列肝脏闪烁扫描。在最初的研究中，锝-99m 二乙三胺五乙酸-半乳糖基人血清白蛋白闪烁扫描上的放射性核素分布与锝-99m 锡胶体闪烁扫描上的完全不同。在 1 个月后的一项随访研究中，肝脏中两种放射性核素的分布显得相对均匀。锝-99m 二乙三胺五乙酸-半乳糖基人血清白蛋白和锝-99m 锡胶体的摄取分别反映了肝细胞和库普弗细胞的功能。两种闪烁扫描研究可能有助于评估不同肝组织结构的组织病理学变化。
