Tomiguchi S, Kira T, Oyama Y, Nabeshima M, Nakashima R, Tsuji A, Kojima A, Takahashi M, Yoshimatsu S, Sagara K
Department of Radiology, Kumamto University School of Medicine, Japan.
Clin Nucl Med. 1995 Aug;20(8):717-20. doi: 10.1097/00003072-199508000-00013.
To determine whether scintigraphic findings of Tc-99m DTPA-galactosyl-HSA (GSA) correspond to histopathologic findings, Tc-99m GSA hepatic scintigraphy and biopsy were compared in 65 patients with chronic active hepatitis. After injecting 185 MBq of Tc-99m GSA, anterior images were obtained at 5 minutes and 15 minutes. Scintigrams were classified into three grades according to the extent of visualization of the cardiac blood pool on 5 minute and 15 minute images. Biopsies were subjectively graded for findings of necrosis and fibrosis. Scintigraphic grades on 5 minute images were correlated with hepatic necrosis and fibrosis and those on 15-minute images with hepatic fibrosis. Scintigraphic abnormalities of Tc-99m GSA correlated well with histopathologic abnormalities, especially with hepatic fibrosis and necrosis in patients with chronic active hepatitis.
为了确定锝-99m二乙三胺五乙酸-半乳糖基人血清白蛋白（GSA）闪烁扫描结果是否与组织病理学结果相符，对65例慢性活动性肝炎患者进行了锝-99m GSA肝脏闪烁扫描和活检并进行比较。注射185MBq的锝-99m GSA后，于5分钟和15分钟时采集前位图像。根据5分钟和15分钟图像中心脏血池的显影程度，将闪烁扫描图分为三个等级。对活检标本的坏死和纤维化情况进行主观分级。5分钟图像的闪烁扫描等级与肝坏死和纤维化相关，15分钟图像的闪烁扫描等级与肝纤维化相关。锝-99m GSA的闪烁扫描异常与组织病理学异常密切相关，尤其是与慢性活动性肝炎患者的肝纤维化和坏死情况。
