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Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences.

作者信息

Kivistö K T, Neuvonen P J, Klotz U

机构信息

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

出版信息

Clin Pharmacokinet. 1994 Jul;27(1):1-5. doi: 10.2165/00003088-199427010-00001.

DOI:10.2165/00003088-199427010-00001
PMID:7955768
Abstract
摘要

相似文献

1
Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences.特非那定代谢的抑制作用。药代动力学和药效学后果。
Clin Pharmacokinet. 1994 Jul;27(1):1-5. doi: 10.2165/00003088-199427010-00001.
2
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3
Inhibition and interaction of cytochrome P450 of Candida krusei with azole antifungal drugs.克柔念珠菌细胞色素P450与唑类抗真菌药物的抑制作用及相互作用
J Med Vet Mycol. 1997 Jan-Feb;35(1):19-25.
4
Applications of primary human hepatocytes in the evaluation of pharmacokinetic drug-drug interactions: evaluation of model drugs terfenadine and rifampin.原代人肝细胞在药代动力学药物-药物相互作用评估中的应用：模型药物特非那定和利福平的评估
Cell Biol Toxicol. 1997 Jul;13(4-5):365-74. doi: 10.1023/a:1007451911843.
5
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JAMA. 1993;269(12):1513-8.
6
Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics.伊曲康唑影响单剂量特非那定的药代动力学及心脏复极的药效学。
J Clin Pharmacol. 1993 Dec;33(12):1201-6. doi: 10.1002/j.1552-4604.1993.tb03920.x.
7
In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction.
J Clin Pharmacol. 1994 Dec;34(12):1222-7. doi: 10.1002/j.1552-4604.1994.tb04735.x.
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9
The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans.氟康唑对特非那定在人体稳态药代动力学及心电图药效学的影响。
Clin Pharmacol Ther. 1993 Jun;53(6):630-6. doi: 10.1038/clpt.1993.83.
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本文引用的文献

1
The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans.氟康唑对特非那定在人体稳态药代动力学及心电图药效学的影响。
Clin Pharmacol Ther. 1993 Jun;53(6):630-6. doi: 10.1038/clpt.1993.83.
2
Understanding consequences of concurrent therapies.了解联合治疗的后果。
JAMA. 1993;269(12):1550-2.
3
Mechanism of the cardiotoxic actions of terfenadine.特非那定心脏毒性作用的机制。
Clin Pharmacokinet. 2007;46(2):133-57. doi: 10.2165/00003088-200746020-00003.
4
Cytochrome P450s and other enzymes in drug metabolism and toxicity.细胞色素P450及其他参与药物代谢和毒性的酶。
AAPS J. 2006 Mar 10;8(1):E101-11. doi: 10.1208/aapsj080112.
5
Hepatic disposition of fexofenadine: influence of the transport inhibitors erythromycin and dibromosulphothalein.非索非那定的肝脏处置：转运抑制剂红霉素和二溴磺酞的影响
Pharm Res. 2000 Dec;17(12):1511-5. doi: 10.1023/a:1007609225851.
6
Effects of imidazole antimycotics on the liver microsomal cytochrome P450 isoforms in rats: comparison of in vitro and ex vivo studies.
Eur J Drug Metab Pharmacokinet. 2000 Apr-Jun;25(2):121-6. doi: 10.1007/BF03190078.
7
Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin.大环内酯类药物与细胞色素P-450A（CYP）3A4的临床相关药物相互作用：聚焦于克拉霉素、阿奇霉素和地红霉素的最新进展
Br J Clin Pharmacol. 2000 Oct;50(4):285-95. doi: 10.1046/j.1365-2125.2000.00261.x.
8
Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.抗真菌药物对氧化药物代谢的影响：临床相关性。
Clin Pharmacokinet. 2000 Feb;38(2):111-80. doi: 10.2165/00003088-200038020-00002.
9
Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.特非那定及其代谢产物在肠上皮Caco-2（TC7）细胞单层中CYP3A介导的代谢与极化外排之间的相互作用。
Pharm Res. 1999 May;16(5):625-32. doi: 10.1023/a:1018851919674.
10
Systemic antifungal agents. Drug interactions of clinical significance.全身性抗真菌药物。具有临床意义的药物相互作用。
Drug Saf. 1998 Feb;18(2):83-97. doi: 10.2165/00002018-199818020-00001.
JAMA. 1993;269(12):1532-6.
4
Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences.特非那定-酮康唑相互作用。药代动力学及心电图影响。
JAMA. 1993;269(12):1513-8.
5
Itraconazole prevents terfenadine metabolism and increases risk of torsades de pointes ventricular tachycardia.伊曲康唑可抑制特非那定的代谢，增加尖端扭转型室性心动过速的风险。
Eur J Clin Pharmacol. 1993;45(2):191-3. doi: 10.1007/BF00315505.
6
Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine.伊曲康唑与特非那定相互作用所致的晕厥和心律失常。
Am J Med. 1993 Oct;95(4):445-6. doi: 10.1016/0002-9343(93)90317-i.
7
Dose of midazolam should be reduced during diltiazem and verapamil treatments.在使用地尔硫䓬和维拉帕米治疗期间，咪达唑仑的剂量应减少。
Br J Clin Pharmacol. 1994 Mar;37(3):221-5. doi: 10.1111/j.1365-2125.1994.tb04266.x.
8
Grapefruit juice and drugs. How significant is the interaction?葡萄柚汁与药物。这种相互作用有多显著？
Clin Pharmacokinet. 1994 Feb;26(2):91-8. doi: 10.2165/00003088-199426020-00002.
9
Pharmacokinetic drug interactions with antimicrobial agents.药物与抗菌药物的药代动力学相互作用。
Clin Pharmacokinet. 1993 Dec;25(6):450-82. doi: 10.2165/00003088-199325060-00005.
10
Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.抗组胺药特非那定在人肝微粒体中的氧化作用。细胞色素P-450 3A(4)在N-脱烷基化和C-羟基化中的作用。
Drug Metab Dispos. 1993 May-Jun;21(3):403-9.