特非那定代谢的抑制作用。药代动力学和药效学后果。 - Suppr

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超能文献

Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences.

作者信息

Kivistö K T, Neuvonen P J, Klotz U

机构信息

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

出版信息

Clin Pharmacokinet. 1994 Jul;27(1):1-5. doi: 10.2165/00003088-199427010-00001.

DOI:10.2165/00003088-199427010-00001

PMID:7955768

Abstract

摘要

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本文引用的文献

Clin Pharmacol Ther. 1993 Jun;53(6):630-6. doi: 10.1038/clpt.1993.83.

Understanding consequences of concurrent therapies.了解联合治疗的后果。

JAMA. 1993;269(12):1550-2.

Mechanism of the cardiotoxic actions of terfenadine.特非那定心脏毒性作用的机制。

JAMA. 1993;269(12):1532-6.

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences.特非那定-酮康唑相互作用。药代动力学及心电图影响。

JAMA. 1993;269(12):1513-8.

Itraconazole prevents terfenadine metabolism and increases risk of torsades de pointes ventricular tachycardia.伊曲康唑可抑制特非那定的代谢，增加尖端扭转型室性心动过速的风险。

Eur J Clin Pharmacol. 1993;45(2):191-3. doi: 10.1007/BF00315505.

Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine.伊曲康唑与特非那定相互作用所致的晕厥和心律失常。

Am J Med. 1993 Oct;95(4):445-6. doi: 10.1016/0002-9343(93)90317-i.

Dose of midazolam should be reduced during diltiazem and verapamil treatments.在使用地尔硫䓬和维拉帕米治疗期间，咪达唑仑的剂量应减少。

Br J Clin Pharmacol. 1994 Mar;37(3):221-5. doi: 10.1111/j.1365-2125.1994.tb04266.x.

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Pharmacokinetic drug interactions with antimicrobial agents.药物与抗菌药物的药代动力学相互作用。

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.抗组胺药特非那定在人肝微粒体中的氧化作用。细胞色素P-450 3A(4)在N-脱烷基化和C-羟基化中的作用。

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