Avogaro A, Crepaldi C, Miola M, Penzo M, Maran A, Zanin L, Rossi G P, Moretti M, Palatini P, Tiengo A
Cattedra di Malattie del Metabolismo, University of Padova, Italy.
Diabet Med. 1994 Jul;11(6):573-7. doi: 10.1111/j.1464-5491.1994.tb02038.x.
This study was performed to assess possible delayed after-effects of acute hypoglycaemia on blood pressure (BP) and heart rate (HR) over a 24-h period. Eleven insulin-dependent diabetic patients and 11 sex, age, and body mass index matched non-diabetic subjects were studied. Blood pressure was measured using a non-invasive ambulatory blood pressure monitor following acutely induced hypoglycaemia in the morning. No significant differences were observed in 24-h systolic and diastolic BP and HR in either groups, between the day when hypoglycaemia was induced and the day when plasma glucose was kept normal. In diabetic patients, hypoglycaemia induced a temporary but significant fall in mean BP (-7 +/- 1 mmHg vs -2 +/- 2; p < 0.05). Plasma glucose levels were significantly higher in insulin-dependent diabetic patients following hypoglycaemia than in those observed during the reference test. This study demonstrates that acute hypoglycaemia in insulin-dependent diabetic subjects does not cause significant alterations in 24-h BP in either diabetic or normal subjects.
本研究旨在评估急性低血糖对血压（BP）和心率（HR）在24小时内可能产生的延迟后效应。研究对象为11名胰岛素依赖型糖尿病患者以及11名在性别、年龄和体重指数方面与之匹配的非糖尿病受试者。早晨急性诱发低血糖后，使用无创动态血压监测仪测量血压。在诱发低血糖的当天与血浆葡萄糖维持正常的当天，两组在24小时收缩压、舒张压及心率方面均未观察到显著差异。在糖尿病患者中，低血糖导致平均血压暂时但显著下降（-7±1 mmHg对比-2±2；p<0.05）。低血糖后，胰岛素依赖型糖尿病患者的血浆葡萄糖水平显著高于参考测试期间的水平。本研究表明，胰岛素依赖型糖尿病受试者发生急性低血糖时，无论是糖尿病患者还是正常受试者，24小时血压均未出现显著变化。
