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Excision repair in man and the molecular basis of xeroderma pigmentosum syndrome.

作者信息

Reardon J T, Thompson L H, Sancar A

机构信息

Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill 27599.

出版信息

Cold Spring Harb Symp Quant Biol. 1993;58:605-17. doi: 10.1101/sqb.1993.058.01.067.

DOI:10.1101/sqb.1993.058.01.067
PMID:7956075
Abstract
摘要

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In vitro DNA repair genomics using XR-seq with and mammalian cell-free extracts.利用 XR-seq 与 和哺乳动物无细胞提取物进行体外 DNA 修复基因组学研究。
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DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair.DCAF7 对于维持 ERCC1-XPF 的细胞水平和核苷酸切除修复是必需的。
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The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif.DNA修复核酸内切酶XPF-ERCC1的活性位点形成一个高度保守的核酸酶基序。
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In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients.人核苷酸切除修复系统对氧化性DNA损伤的体外修复:着色性干皮病患者神经退行性变的可能解释。
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Nucleic Acids Res. 1997 Mar 1;25(5):1015-21. doi: 10.1093/nar/25.5.1015.