Javitt J C, Aiello L P, Chiang Y, Ferris F L, Canner J K, Greenfield S
Worthen Center for Eye Care Research, Georgetown University Medical Center, Washington, DC.
Diabetes Care. 1994 Aug;17(8):909-17. doi: 10.2337/diacare.17.8.909.
Diabetic retinopathy, which leads to macular edema and retinal neovascularization, is the leading cause of blindness among working-age Americans. Previous research has demonstrated significant cost savings associated with detection of eye disease in Americans with type I diabetes. However, detection and treatment of eye disease among those with type II diabetes was previously thought not to be cost-saving. Our purpose was to estimate the current and potential federal savings resulting from the screening and treatment of retinopathy in patients with type II diabetes, based on recently available data concerning efficacy of treating both macular edema and neovascularization along with new data on federal budgetary costs of blindness.
We used computer modeling, incorporating data from population-based epidemiological studies and multicenter clinical trials. Monte Carlo simulation was used, combined with sensitivity analysis and present value analysis of cost savings.
Screening and treatment for eye disease in patients with type II diabetes generates annual savings of $247.9 million to the federal budget and 53,986 person-years of sight, even at current suboptimal (60%) levels of care. If all patients with type II diabetes receive recommended care, the predicted net savings (discounted at 5%) exceeds $472.1 million and 94,304 person-years of sight. Nearly all savings are associated with detection and treatment of diabetic macular edema. Enrolling each additional person with type II diabetes into currently recommended ophthalmological care results in an average net savings of $975/person, even if all costs of care are borne by the federal government.
Our analysis indicates that prevention programs aimed at improving eye care for patients with diabetes not only reduce needless vision loss but also will provide a financial return on the investment of public funds.
糖尿病视网膜病变会导致黄斑水肿和视网膜新生血管形成,是美国工作年龄人群失明的主要原因。先前的研究表明,对1型糖尿病美国人进行眼病检测可节省大量成本。然而,先前认为对2型糖尿病患者进行眼病检测和治疗并不节省成本。我们的目的是根据最近关于治疗黄斑水肿和新生血管形成的疗效数据以及关于失明的联邦预算成本的新数据,估计对2型糖尿病患者进行视网膜病变筛查和治疗当前及潜在的联邦节省情况。
我们使用计算机建模,纳入基于人群的流行病学研究和多中心临床试验的数据。采用蒙特卡洛模拟,并结合成本节省的敏感性分析和现值分析。
即使在当前护理水平不理想(60%)的情况下,对2型糖尿病患者进行眼病筛查和治疗每年可为联邦预算节省2.479亿美元,并挽救53986人年的视力。如果所有2型糖尿病患者都接受推荐的护理,预计净节省(按5%贴现)超过4.721亿美元和94304人年的视力。几乎所有节省都与糖尿病黄斑水肿的检测和治疗有关。即使所有护理费用均由联邦政府承担,每增加一名2型糖尿病患者接受当前推荐的眼科护理,平均净节省为每人975美元。
我们的分析表明,旨在改善糖尿病患者眼部护理的预防计划不仅可减少不必要的视力丧失,还将为公共资金投资带来经济回报。