Elsheikh T M, Bernacki E G, Pisharodi L
Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan.
Diagn Cytopathol. 1994;11(1):47-51. doi: 10.1002/dc.2840110111.
Salivary duct carcinoma (SDC) is an extremely rare and highly aggressive primary epithelial neoplasm of the salivary glands associated with increased tendency for lymph node and vascular metastases. Histologically, this lesion resembles intraductal cribriform and comedo carcinoma of the breast. Fine-needle aspiration (FNA) cytology of SDC in two patients with parotid masses (ages 65 and 67) is presented. The aspirates were sparsely to richly cellular and contained predominantly broad flat and branching sheets of large polygonal epithelial cells with abundant eosinophilic cytoplasm, round to oval nuclei, finely granular chromatin and prominent nucleoli. Few sheets showed cribriforming and papillary configuration. The cytologic differential diagnosis included oncocytoma, acinic cell carcinoma, muco-epidermoid carcinoma, and metastatic adenocarcinoma. To the best of our knowledge, this is the first report to describe a spectrum of cytologic features that may allow a specific FNA diagnosis of SDC. Preoperative diagnosis of this neoplasm may warrant a more extensive radiologic workup and therapy including radical surgery and neck dissection followed by radiation therapy.
涎腺导管癌（SDC）是一种极其罕见且具有高度侵袭性的涎腺原发性上皮性肿瘤，伴有淋巴结和血管转移倾向增加。组织学上，该病变类似于乳腺导管内筛状癌和粉刺癌。本文介绍了两名患有腮腺肿块（年龄分别为65岁和67岁）的患者的涎腺导管癌细针穿刺（FNA）细胞学检查结果。吸出物细胞数量稀少至丰富，主要包含大量多边形上皮细胞组成的宽大扁平及分支状细胞片，这些细胞具有丰富的嗜酸性细胞质、圆形至椭圆形细胞核、细颗粒状染色质和明显的核仁。少数细胞片显示筛状和乳头状结构。细胞学鉴别诊断包括嗜酸细胞瘤、腺泡细胞癌、黏液表皮样癌和转移性腺癌。据我们所知，这是第一份描述一系列细胞学特征的报告，这些特征可能有助于对涎腺导管癌进行特异性FNA诊断。对该肿瘤进行术前诊断可能需要更广泛的影像学检查和治疗，包括根治性手术和颈部清扫，随后进行放射治疗。
