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相似文献

1
Some genetic consequences of changes in the level of recA gene function in Escherichia coli K-12.大肠杆菌K-12中recA基因功能水平变化的一些遗传后果。
Genetics. 1976 Dec;84(4):675-95. doi: 10.1093/genetics/84.4.675.
2
Temperature-sensitive recA mutant of Escherichia coli K-12: deoxyribonucleic acid metabolism after ultraviolet irradiation.大肠杆菌K-12的温度敏感型recA突变体：紫外线照射后的脱氧核糖核酸代谢
J Bacteriol. 1975 Mar;121(3):892-900. doi: 10.1128/jb.121.3.892-900.1975.
3
Conjugational recombination in Escherichia coli: genetic analysis of recombinant formation in Hfr x F- crosses.大肠杆菌中的接合重组：Hfr×F-杂交中重组体形成的遗传分析
Genetics. 1995 Mar;139(3):1123-48. doi: 10.1093/genetics/139.3.1123.
4
Recombinant F' factors from Escherichia coli K-12 strains carrying recB or recC.来自携带recB或recC的大肠杆菌K-12菌株的重组F'因子。
J Bacteriol. 1972 May;110(2):578-84. doi: 10.1128/jb.110.2.578-584.1972.
5
[Revertants of recA-strains of Escherichia coli K-12].[大肠杆菌K-12 recA菌株的回复突变体]
Genetika. 1976;12(1):98-110.
6
Ultraviolet light-induced plasmid-chromosome recombination in Escherichia coli: the role of recB and recF.紫外线诱导大肠杆菌中质粒与染色体的重组：recB和recF的作用
Gene. 1991 Jan 2;97(1):131-6. doi: 10.1016/0378-1119(91)90020-c.
7
Hyper-recombination in Escherichia coli K-12 mutants constitutive for protein X synthesis.大肠杆菌K-12中蛋白质X合成组成型突变体的超重组。
J Bacteriol. 1978 Jun;134(3):929-35. doi: 10.1128/jb.134.3.929-935.1978.
8
Isolation and characterization of an Escherichia coli K-12 mutant with a temperature-sensitive recA- phenotype.一株具有温度敏感型recA-表型的大肠杆菌K-12突变体的分离与鉴定。
J Bacteriol. 1974 Oct;120(1):407-15. doi: 10.1128/jb.120.1.407-415.1974.
9
Linkage distortion following conjugational transfer of sbcC+ to recBC sbcBC strains of Escherichia coli.sbcC⁺向大肠杆菌recBC sbcBC菌株进行接合转移后的连锁畸变。
J Bacteriol. 1991 Sep;173(18):5694-8. doi: 10.1128/jb.173.18.5694-5698.1991.
10
Hyper-recombination in uvrD mutants of Escherichia coli K-12.大肠杆菌K-12的uvrD突变体中的超重组
Mol Gen Genet. 1980;180(1):185-91. doi: 10.1007/BF00267368.

引用本文的文献

1
Conjugational recombination in Escherichia coli: genetic analysis of recombinant formation in Hfr x F- crosses.大肠杆菌中的接合重组：Hfr×F-杂交中重组体形成的遗传分析
Genetics. 1995 Mar;139(3):1123-48. doi: 10.1093/genetics/139.3.1123.
2
Damage to DNA induces expression of the ruv gene of Escherichia coli.DNA损伤会诱导大肠杆菌ruv基因的表达。
Mol Gen Genet. 1982;185(2):352-5. doi: 10.1007/BF00330811.
3
Hyper-recombination in uvrD mutants of Escherichia coli K-12.大肠杆菌K-12的uvrD突变体中的超重组
Mol Gen Genet. 1980;180(1):185-91. doi: 10.1007/BF00267368.
4
Recombination properties of P1 dlac.P1 dlac的重组特性
J Bacteriol. 1982 Oct;152(1):345-50. doi: 10.1128/jb.152.1.345-350.1982.
5
Enhanced recombination between F42lac and lambda plac5: dependence on F42lac fertility functions.F42lac与λplac5之间增强的重组：对F42lac育性功能的依赖性。
Mol Gen Genet. 1981;184(3):355-8. doi: 10.1007/BF00352504.
6
Suppressor mutations (rin) that specifically suppress the recA+ dependence of stable DNA replication in Escherichia coliK-12.抑制突变（rin），其可特异性抑制大肠杆菌K-12中稳定DNA复制对recA+的依赖性。
Mol Gen Genet. 1982;187(2):225-30. doi: 10.1007/BF00331121.
7
A molecular model for conjugational recombination in Escherichia coli K12.大肠杆菌K12中接合重组的分子模型。
Mol Gen Genet. 1984;197(2):328-36. doi: 10.1007/BF00330981.
8
Negative complementation of recA protein by recA1 polypeptide: in vivo recombination requires a multimeric form of recA protein.recA1多肽对recA蛋白的负互补作用：体内重组需要recA蛋白的多聚体形式。
Mol Gen Genet. 1984;193(1):53-7. doi: 10.1007/BF00327413.
9
Effect of ruv mutations on recombination and DNA repair in Escherichia coli K12.鲁夫突变对大肠杆菌K12中重组和DNA修复的影响。
Mol Gen Genet. 1984;194(1-2):303-9. doi: 10.1007/BF00383532.
10
Stimulation of recombination between homologous sequences on plasmid DNA and chromosomal DNA in Escherichia coli by N-acetoxy-2-acetylaminofluorene.N-乙酰氧基-2-乙酰氨基芴对大肠杆菌中质粒DNA与染色体DNA同源序列间重组的刺激作用。
Proc Natl Acad Sci U S A. 1984 May;81(9):2831-5. doi: 10.1073/pnas.81.9.2831.

本文引用的文献

1
Replica plating and indirect selection of bacterial mutants.细菌突变体的影印培养和间接筛选
J Bacteriol. 1952 Mar;63(3):399-406. doi: 10.1128/jb.63.3.399-406.1952.
2
Some properties of excision-defective recombination-deficient mutants of Escherichia coli K-12.大肠杆菌K-12切除缺陷型重组缺陷型突变体的一些特性
J Bacteriol. 1969 Mar;97(3):1134-41. doi: 10.1128/jb.97.3.1134-1141.1969.
3
Formation of merodiploids in matings with a class of Rec- recipient strains of Escherichia coli K12.在与一类大肠杆菌K12 Rec-受体菌株交配时形成部分二倍体。
Proc Natl Acad Sci U S A. 1968 May;60(1):160-7. doi: 10.1073/pnas.60.1.160.
4
The genetic location of the sbcA gene of Escherichia coli.大肠杆菌sbcA基因的遗传定位。
Mol Gen Genet. 1974;134(2):157-71. doi: 10.1007/BF00268417.
5
Detection of transcribable recombination products following conjugation in rec+, reCB- and recC-strains of Escherichia coli K12.在大肠杆菌K12的rec +、reCB - 和recC - 菌株中接合后可转录重组产物的检测。
J Mol Biol. 1974 Mar 15;83(4):447-57. doi: 10.1016/0022-2836(74)90506-3.
6
Prophage induction and cell division in E. coli. II. Linked (recA, zab) and unlinked (lex) suppressors of tif-1-mediated induction and filamentation.大肠杆菌中的原噬菌体诱导与细胞分裂。II. tif-1介导的诱导和丝状化的连锁（recA、zab）和非连锁（lex）抑制因子
Mol Gen Genet. 1972;119(2):153-74. doi: 10.1007/BF00269134.
7
Recombinant F' factors from Escherichia coli K-12 strains carrying recB or recC.来自携带recB或recC的大肠杆菌K-12菌株的重组F'因子。
J Bacteriol. 1972 May;110(2):578-84. doi: 10.1128/jb.110.2.578-584.1972.
8
Conjugation in Escherichia coli: a study of recombination and the fate of donor DNA at the level of the zygote.
Mol Gen Genet. 1975;137(1):1-10. doi: 10.1007/BF00332536.

大肠杆菌K-12中recA基因功能水平变化的一些遗传后果。

Some genetic consequences of changes in the level of recA gene function in Escherichia coli K-12.

作者信息

Lloyd R G, Low B

出版信息

Genetics. 1976 Dec;84(4):675-95. doi: 10.1093/genetics/84.4.675.

DOI:10.1093/genetics/84.4.675
PMID:795714
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213602/
Abstract

Genetic recombination was studied in E. coli mutants that carry lesions in the recA gene but retain some capacity for generating recombinant progeny. We observed that recombination was detectable only at a very low level during the incubation of leaky RecA- merozygotes in broth. However, recombination appeared to occur at much higher frequencies when recombinant progeny were assayed by selection on minimal agar. Analysis of the recombinants obtained with Hfr donors revealed a deficiency of multiple exchanges per unit length of DNA in leaky RecA- strains. In many of these crosses recombinants that inherited donor alleles close to the transfer origin were much reduced in frequency, except when the recipient was also RecB-.

摘要

在携带recA基因损伤但仍保留一定产生重组后代能力的大肠杆菌突变体中研究了基因重组。我们观察到，在肉汤中培养渗漏型RecA - 部分二倍体时，仅能以非常低的水平检测到重组。然而，当通过在基本琼脂上进行选择来检测重组后代时，重组似乎以高得多的频率发生。对用高频重组（Hfr）供体获得的重组体的分析表明，渗漏型RecA - 菌株中每单位长度DNA的多次交换存在缺陷。在许多这样的杂交中，除了受体也是RecB - 的情况外，继承靠近转移起点的供体等位基因的重组体频率大大降低。