Concia E, Cruciani M, Bartucci F, Arrigoni L, Longoni A
Istituto di Malattie Infettive, Ospedale Borgo Trento, Verona, Italy.
Eur J Clin Pharmacol. 1994;46(4):371-3. doi: 10.1007/BF00194408.
To obtain further information about the availability of salmon calcitonin in the biophase compartment that surrounds the receptor site, salmon calcitonin concentrations in plasma and skin blister fluid (SBF) after a single i.v. dose of 100 IU synthetic salmon calcitonin were compared in 15 healthy volunteers. Serial blood and SBF samples were collected before and up to 8 h after administration and calcitonin was determined by a specific RIA. The maximum concentration in plasma was 225 pg.ml-1 (in the first sample at 15 min), whereas in SBF the mean peak of 84 pg.ml-1 was reached after about 30 min. The distribution of salmon calcitonin into SBF, defined as the ratio of the AUCs in SBF and plasma, was 1.5. The kinetic profiles of salmon calcitonin in plasma and interstitial fluid were different. Calcitonin in plasma peaked and then levelled out, while in SBF it persisted longer than in plasma. This is the first report of the distribution of salmon calcitonin into blister fluid.
为获取有关受体位点周围生物相区室中鲑鱼降钙素可用性的更多信息，在15名健康志愿者中比较了单次静脉注射100 IU合成鲑鱼降钙素后血浆和皮肤疱液（SBF）中的鲑鱼降钙素浓度。在给药前及给药后长达8小时采集系列血液和SBF样本，并通过特异性放射免疫分析法测定降钙素。血浆中的最大浓度为225 pg.ml-1（在15分钟时的首个样本中），而在SBF中，约30分钟后达到平均峰值84 pg.ml-1。鲑鱼降钙素在SBF中的分布定义为SBF与血浆中曲线下面积（AUC）之比，为1.5。鲑鱼降钙素在血浆和组织液中的动力学曲线不同。血浆中的降钙素达到峰值后趋于平稳，而在SBF中其持续时间比在血浆中更长。这是关于鲑鱼降钙素在疱液中分布的首篇报道。
