采用抽吸皮肤水疱、皮肤窗口和皮肤小室技术来确定头孢噻肟在人体的血管外通透情况。
Suction skin blister, skin window, and skin chamber techniques to determine extravascular passage of cefotaxime in humans.
作者信息
Frongillo R F, Galuppo L, Moretti A
出版信息
Antimicrob Agents Chemother. 1981 Jan;19(1):22-8. doi: 10.1128/AAC.19.1.22.
Abstract
We report the results obtained in comparative study on the extravascular passage of cefotaxime, employing three different methods: suction skin blister, skin window, and skin chamber. Applying the skin blister method in two different ways, we also studied the influence that suction pressure and time lapse between blister formation and antibiotic injection had on the results obtained in order to standardize the method and establish repeatability of the results. Using the skin chamber method, we studied the influence that the different protein contents in the fluid used to fill the skin chamber had on extravascular concentrations.
摘要
我们报告了采用三种不同方法（吸疱法、皮肤窗法和皮肤小室法）对头孢噻肟血管外通透情况进行比较研究所得的结果。通过两种不同方式应用皮肤吸疱法，我们还研究了吸疱压力以及吸疱形成至注射抗生素之间的时间间隔对所得结果的影响，以便规范该方法并确立结果的可重复性。使用皮肤小室法，我们研究了用于填充皮肤小室的液体中不同蛋白质含量对血管外浓度的影响。
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