Yeterian E H, Pandya D N
Department of Psychology, Colby College, Waterville, ME 04901.
Exp Brain Res. 1994;99(3):383-98. doi: 10.1007/BF00228975.
Prefrontostriatal and prefrontothalamic connections in rhesus monkeys have been shown to be organized in a topographic manner. These projections originate largely from infragranular layers V and VI. To examine whether the striatal and thalamic connections from the prefrontal cortex arise from separate neuronal populations or are collateralized, two different fluorescent retrograde tracers (diamidino yellow and fast blue) were injected into topographically similar regions of the head of the caudate nucleus and the mediodorsal nucleus in the same animal. The results show that although prefrontostriatal and prefrontothalamic projections arise from similar topographic regions, their laminar origins are distinctive. The connections to the head of the caudate nucleus originate mainly from layer Va, to a lesser extent from layer Vb, with a minor contribution from layers III and VI. In contrast, the projections to the mediodorsal nucleus emanate largely from layer VI, and also from layer Vb. Only occasional double-labeled neurons were observed, indicating that prefrontostriatal and prefrontothalamic connections originate from separate neuronal populations. The differential laminar distributions of neurons projecting to the head of the caudate nucleus and the mediodorsal nucleus suggest that these structures may receive independent types of information from the prefrontal cortex.
恒河猴的前额叶纹状体和前额叶丘脑连接已被证明是以拓扑方式组织的。这些投射主要起源于V层和VI层颗粒下层。为了研究前额叶皮质与纹状体和丘脑的连接是来自不同的神经元群体还是有侧支，将两种不同的荧光逆行示踪剂（双脒基黄和快蓝）注射到同一只动物尾状核头部和背内侧核的拓扑相似区域。结果表明，虽然前额叶纹状体和前额叶丘脑投射起源于相似的拓扑区域，但其层状起源是不同的。与尾状核头部的连接主要起源于Va层，其次是Vb层，III层和VI层贡献较小。相比之下，投向背内侧核的投射主要来自VI层，也来自Vb层。仅偶尔观察到双标记神经元，表明前额叶纹状体和前额叶丘脑连接起源于不同的神经元群体。投射到尾状核头部和背内侧核的神经元的不同层状分布表明，这些结构可能从前额叶皮质接收独立类型的信息。
