Khatkhatay I, Desai M P, Sheth A R
Department of Biochemistry, Institute for Research in Reproduction (ICMR), Parel, Bombay, India.
Eur J Obstet Gynecol Reprod Biol. 1994 Jun 15;55(2):117-21. doi: 10.1016/0028-2243(94)90065-5.
The excretory profile of inhibin-like peptide (10.4 kDa) and its interrelationship with urinary LH, FSH, oestrone glucuronide (E1G) and pregnanediol glucuronide (PdG) during the menstrual cycle were studied. These hormones/metabolites were estimated in daily early morning urine samples obtained from 20 regularly menstruating women. The data revealed that the excretory profile of inhibin-like peptide (ILP) follows a pattern similar to that of E1G. In 17 cycles, ILP peaked 3-4 days prior to the urinary LH peak. A value of 70 ng/mg creatinine (95th centile of ILP levels obtained between 2 and 4 days prior to urinary LH peak and also 5th centile of peak ILP levels) was considered as an indicator of the start of the fertile period. A value of PdG more than 2 micrograms/mg creatinine on two consecutive days was considered as an end of the fertile period. The entire fertile period could be determined in 18 out 20 cycles when criteria based on ILP and PdG levels were applied (accuracy, 90%), whereas it could be determined in 13 out of 20 cycles when criteria based on E1G and PdG levels were applied (accuracy, 65%). Thus, ILP levels in urine may prove to be one of the signals for determining the start of fertile period.
研究了抑制素样肽（10.4 kDa）的排泄情况及其在月经周期中与尿促黄体生成素（LH）、促卵泡生成素（FSH）、雌酮葡萄糖醛酸苷（E1G）和孕二醇葡萄糖醛酸苷（PdG）的相互关系。从20名月经周期规律的女性中获取每日清晨尿样，对这些激素/代谢物进行了测定。数据显示，抑制素样肽（ILP）的排泄情况与E1G相似。在17个周期中，ILP在尿LH峰值前3 - 4天达到峰值。70 ng/mg肌酐的值（尿LH峰值前2至4天ILP水平的第95百分位数，也是ILP峰值水平的第5百分位数）被视为排卵期开始的指标。连续两天PdG值超过2微克/mg肌酐被视为排卵期结束。当应用基于ILP和PdG水平的标准时，20个周期中有18个周期可以确定整个排卵期（准确率90%）；而当应用基于E1G和PdG水平的标准时，20个周期中有13个周期可以确定（准确率65%）。因此，尿中ILP水平可能被证明是确定排卵期开始的信号之一。
