Mercelina-Roumans P E, Ubachs J M, van Wersch J W
Department of Obstetrics and Gynaecology, De Wever Hospital, Heerlen, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 1994 Jun 30;55(3):169-73. doi: 10.1016/0028-2243(94)90033-7.
The total leucocyte count was studied in 194 smoking and 518 non-smoking healthy pregnant women. Smoking in pregnancy appeared to have an additive enhancing effect on the already known total leucocyte increase in pregnancy. The leucocyte differential in 105 smoking and 288 non-smoking pregnant women showed that the eosinophil and basophil count was not involved in the white blood cell shift. The rise of the total leucocyte count was mainly due to an increase of neutrophils, monocytes and lymphocytes. The leucocytosis in the smoking pregnant women was dose-related: significant upward jumps of the percentages of leucocytosis were observed between 12 and 15 cigarettes/day as well as between 19 and 20 cigarettes/day. Further investigation as to the relevance of these observations for pregnancy and fetal well being has to be conducted.
对194名吸烟的健康孕妇和518名不吸烟的健康孕妇进行了白细胞总数研究。孕期吸烟似乎对孕期已知的白细胞总数增加有累加增强作用。对105名吸烟孕妇和288名不吸烟孕妇的白细胞分类计数显示，嗜酸性粒细胞和嗜碱性粒细胞计数与白细胞变化无关。白细胞总数的增加主要是由于中性粒细胞、单核细胞和淋巴细胞的增多。吸烟孕妇的白细胞增多与剂量相关：每天吸12至15支烟以及每天吸19至20支烟时，白细胞增多百分比出现显著跃升。必须对这些观察结果与妊娠及胎儿健康的相关性进行进一步研究。
