Liubomirskaia N V, Shostak N G, Kuzin A B, Khudaĭbergenova B M, Il'in Iu V, Kim A I
Genetika. 1994 Jun;30(6):743-8.
A previously described system of a Drosophila melanogaster mutative strain (MS), which originates from a stable strain (SS), is characterized by genetic instability caused by transposition of the retrotransposon gypsy. New unstable strains were obtained by microinjections of the gypsy transposable copy into SS embryos. In situ hybridization experiments revealed amplification and active transposition of gypsy in SS derivatives. At the same time, introduction of the gypsy transposable copy into another stable strain (208) did not lead to appearance of genetic instability. Genetic instability in the MS system is apparently induced by a combination of two factors: the presence of a gypsy transposable copy and mutation(s) in the gene(s) regulating its transpositions.
一种先前描述的源自稳定品系（SS）的黑腹果蝇突变品系（MS）系统，其特征是由反转录转座子gypsy的转座引起的遗传不稳定性。通过将gypsy转座拷贝显微注射到SS胚胎中获得了新的不稳定品系。原位杂交实验揭示了gypsy在SS衍生物中的扩增和活跃转座。同时，将gypsy转座拷贝引入另一个稳定品系（208）并未导致遗传不稳定性的出现。MS系统中的遗传不稳定性显然是由两个因素共同诱导的：gypsy转座拷贝的存在以及调节其转座的基因中的突变。
