Asachenkov A L, Marchuk G I, Mohler R R, Zuev S M
International Institute for Applied Systems Analysis, Department of Systems and Decision Sciences, Laxenburg, Austria.
IEEE Trans Biomed Eng. 1994 Oct;41(10):943-53. doi: 10.1109/10.324526.
The application of system theory (or more precisely, differential equations) to immunology and disease, in general, is presented here. Particular results from U.S.-Russian research collaboration depict the potential role of such systematic analysis for more effective health care and disease control. In particular, some emphasis is given to control of influenza. After a brief systematic overview of immunology, a simple infectious disease model is developed to explain four basic forms of disease: subclinical, acute, lethal and chronic. Then, disease treatment is studied.
本文介绍了系统理论（或者更准确地说，微分方程）在免疫学和疾病领域的一般应用。美俄研究合作的具体成果描述了这种系统分析在更有效的医疗保健和疾病控制方面的潜在作用。特别是，重点讨论了流感的控制。在对免疫学进行简要的系统概述之后，建立了一个简单的传染病模型来解释疾病的四种基本形式：亚临床型、急性型、致死型和慢性型。然后，对疾病治疗进行了研究。
