银杏叶提取物对实验性糖尿病脑电图谱的影响：与脂质过氧化无关。

The effect of ginkgo biloba extract on EEG spectra in experimental diabetes: no relation to lipid peroxidation.

作者信息

Ağar A, Yargiçoğlu P, Apaydin K C, Oğuz Y

机构信息

Department of Physiology & Biophysics, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

出版信息

Int J Neurosci. 1994 Jun;76(3-4):259-66. doi: 10.3109/00207459408986008.

DOI:10.3109/00207459408986008

PMID:7960482

Abstract

Forty four Swiss albino rats aged two months, weighing 180-250 g, were used in the experiment. They were divided into four equal groups as control, alloxan-diabetic, diabetic + GbE and control + GbE. After the onset of experimental period, diabetic + GbE and control + GbE groups received ginkgo biloba extract and the other groups were given saline solution for ten weeks. Diabetic and diabetic + GbE groups were made diabetic by injecting alloxan on 16th day. Spectral analysis of EEGs recorded from parietal lobes of all groups of rats were computed by Fast Fourier Transform (FFT) algorithm. Their amplitude maxima were found to occupy the frequency bands of 1-2, 2-4, 4-6, 6-8, 8-16 and 16-30 Hz. Significant amplitude increase was found in 1-2 and 2-4 Hz frequency bands in diabetic + GbE group compared with control, but no differences were found for other groups.

摘要

44只两个月大、体重180 - 250克的瑞士白化大鼠用于该实验。它们被分为四组，每组数量相等，分别为对照组、四氧嘧啶糖尿病组、糖尿病 + 银杏叶提取物组和对照组 + 银杏叶提取物组。实验期开始后，糖尿病 + 银杏叶提取物组和对照组 + 银杏叶提取物组接受银杏叶提取物，其他组给予生理盐水，持续十周。糖尿病组和糖尿病 + 银杏叶提取物组在第16天通过注射四氧嘧啶诱导糖尿病。通过快速傅里叶变换（FFT）算法对所有大鼠组顶叶记录的脑电图进行频谱分析。发现它们的最大振幅占据1 - 2、2 - 4、4 - 6、6 - 8、8 - 16和16 - 30赫兹的频段。与对照组相比，糖尿病 + 银杏叶提取物组在1 - 2和2 - 4赫兹频段的振幅显著增加，但其他组未发现差异。