Martinez S M, Tarrés M C, Montenegro S M, Varela M, Torrano A, D'Ottavio A E, Naves A, Picena J C
Faculty of Medical Sciences, National University of Rosario, Argentina.
Isr J Med Sci. 1994 Oct;30(10):761-6.
The eSS rat is a model of human spontaneous non-insulin-dependent diabetes. Male eSS rats were divided at the age of 4 months into two groups (eSSA and eSSB), both receiving the usual commercial balanced diet with sucrose also made available to eSSA. Sucrose intake did not imply a higher caloric diet, and no differences were found between groups in body weight and plasma triglyceride levels from 6 to 12 months of age. Sucrose option resulted in lower protein, lipid and carbohydrate intakes in eSSA animals. Plasma glucose values were higher in eSSA at different times of the tolerance curve. Likewise, eSSA kidneys showed significantly higher capsular and glomerular diameters and there was a discrete PAS-positive thickening of their basement membrane. We conclude that prolonged ad libitum sucrose intake, without weight gain, causes a moderate metabolic impairment and renal lesions in the eSS diabetic rat.
eSS大鼠是人类自发性非胰岛素依赖型糖尿病的一种模型。雄性eSS大鼠在4月龄时被分为两组（eSSA组和eSSB组），两组均给予常规商业平衡饮食，eSSA组还可自由摄取蔗糖。蔗糖摄入并不意味着热量更高的饮食，6至12月龄时两组在体重和血浆甘油三酯水平上未发现差异。选择蔗糖导致eSSA组动物的蛋白质、脂质和碳水化合物摄入量降低。在耐受曲线的不同时间点，eSSA组的血浆葡萄糖值更高。同样，eSSA组大鼠的肾脏包膜和肾小球直径显著增大，其基底膜有离散的PAS阳性增厚。我们得出结论，在不增加体重的情况下，长期随意摄入蔗糖会导致eSS糖尿病大鼠出现中度代谢损害和肾脏病变。
