Tarrés M C, Martínez S M, Montenegro S M, Picena J C, Naves A, Figueroa N S, Rabasa S L
Cátedra de Biología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Medicina (B Aires). 1990;50(3):235-43.
The long-term effect of feeding eSS rats three commercial diets on the development of diabetes and its complications has been investigated. These diets differ in their proportions of carbohydrates, fibres, lipids and proteins: diet A is rich in lipids, B in carbohydrates and fibres and C in proteins. However, the proportions of these components lie within the range recommended for rats. Animals receiving diet C showed the highest growth rate and were the first to develop diabetes at the age of four months. They had, moreover, the highest levels of triglycerides, total cholesterol and HDL-cholesterol. Animals fed the A diet were heavier than the other groups at 13 months of age, showing a diabetic glucose tolerance test and the highest values of circulating insulin. They were already diabetic when tested at the age of 6 months. The group fed the B diet remained leaner than the other groups and free of diabetes up to the test performed when they were ten months old. The findings at the age of 23 months were: the A animals developed the largest retroperitoneal and epididymal adipose tissue masses, the C group was the most affected by cataracts which were total, and bilateral in some cases, whereas the B rats were free of them and the A animals showed milder lesions than the C rats. Histological studies of pancreas and kidneys demonstrated that the C animals had fewer Langerhans islands than the other groups and the most severe renal lesions while the B animals had no renal damage. It is concluded that diets leading to overweight, particularly those rich in proteins, make the diabetic syndrome worse in eSS rats.
研究了给eSS大鼠喂食三种商业饮食对糖尿病及其并发症发展的长期影响。这些饮食在碳水化合物、纤维、脂质和蛋白质的比例上有所不同：饮食A富含脂质，饮食B富含碳水化合物和纤维，饮食C富含蛋白质。然而，这些成分的比例在推荐给大鼠的范围内。接受饮食C的动物生长速度最快，并且在四个月大时最早患上糖尿病。此外，它们的甘油三酯、总胆固醇和高密度脂蛋白胆固醇水平最高。喂食饮食A的动物在13个月大时比其他组更重，表现出糖尿病葡萄糖耐量试验和循环胰岛素的最高值。它们在6个月大时接受测试时已经患有糖尿病。喂食饮食B的组比其他组更瘦，在10个月大时进行测试之前没有患糖尿病。23个月大时的研究结果如下：饮食A组的动物腹膜后和附睾脂肪组织块最大，饮食C组受白内障影响最严重，在某些情况下白内障是完全的且双侧的，而饮食B组的大鼠没有白内障，饮食A组的动物病变比饮食C组的大鼠轻。胰腺和肾脏的组织学研究表明，饮食C组的动物胰岛比其他组少，肾脏病变最严重，而饮食B组的动物没有肾脏损伤。得出的结论是，导致超重的饮食，尤其是富含蛋白质的饮食，会使eSS大鼠的糖尿病综合征恶化。
