Schnetter D, Haneke E
Hautklinik, Ferdinand-Sauerbruch-Klinikums Wuppertal.
Hautarzt. 1994 Sep;45(9):635-8. doi: 10.1007/s001050050141.
A case simulating extraordinarily extensive chronic vegetating pyoderma revealed itself in its course to be pyoderma gangrenosum. The bacterial flora varied due to a secondary colonization; there was no response to antibiotics but there was to corticosteroid, azathioprine and clofazimine therapy. IgA-paraproteinemia was found. Pyoderma gangrenosum has historically been considered to be a chronic ulcerous pyoderma and is not a disease of bacterial origin. Reviewing the literature available since the turn of this century, chronic vegetating pyoderma is compared with the latter from the viewpoint of clinical features, histopathology, immunology, course and treatment. There are so many convincing parallels between the two conditions that we would like to propose that we stop regarding them as distinct entities and instead view them as parts of a spectrum of the same immunopathological process.
一例模拟极其广泛的慢性增殖性脓皮病的病例，在病程中显示为坏疽性脓皮病。由于继发性定植，细菌菌群有所不同；对抗生素无反应，但对皮质类固醇、硫唑嘌呤和氯法齐明治疗有反应。发现了IgA副蛋白血症。坏疽性脓皮病在历史上一直被认为是一种慢性溃疡性脓皮病，并非细菌源性疾病。回顾本世纪之交以来的现有文献，从临床特征、组织病理学、免疫学、病程和治疗等方面将慢性增殖性脓皮病与坏疽性脓皮病进行了比较。这两种情况之间有如此多令人信服的相似之处，以至于我们建议不再将它们视为不同的实体，而是将它们视为同一免疫病理过程谱的一部分。
