• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

枯草芽孢杆菌营养型过氧化氢酶基因表达的双重调控机制分析。

Analysis of the dual regulatory mechanisms controlling expression of the vegetative catalase gene of Bacillus subtilis.

作者信息

Bol D K, Yasbin R E

机构信息

Department of Biological Sciences, University of Maryland Baltimore County 21228.

出版信息

J Bacteriol. 1994 Nov;176(21):6744-8. doi: 10.1128/jb.176.21.6744-6748.1994.

DOI:10.1128/jb.176.21.6744-6748.1994
PMID:7961428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC197032/
Abstract

The expression of a vegetative catalase gene, katA (formerly the kat-19 gene), is necessary to protect Bacillus subtilis from H2O2, presumably by removing the oxidant from the environment. Genetic analysis of katA revealed that this gene is under two distinct forms of regulation, temporal and H2O2 inducible. The results reported here demonstrate that (i) the H2O2-inducible regulation of katA gene is not a component of the SOS regulon, (ii) the regulatory genes spo0A and abrB are involved in the temporal regulation but not the H2O2-specific induction of katA gene expression, and (iii) transcription initiation for the katA gene occurs at the same site under both forms of regulation.

摘要

一种营养型过氧化氢酶基因katA（以前称为kat - 19基因）的表达对于保护枯草芽孢杆菌免受H2O2的侵害是必需的，大概是通过从环境中去除氧化剂来实现。katA的遗传分析表明，该基因受两种不同形式的调控，即时间调控和H2O2诱导调控。此处报道的结果表明：（i）katA基因的H2O2诱导调控不是SOS调控子的组成部分；（ii）调控基因spo0A和abrB参与时间调控，但不参与katA基因表达的H2O2特异性诱导；（iii）katA基因的转录起始在两种调控形式下都发生在同一位置。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b36/197032/ef47ef4af539/jbacter00039-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b36/197032/ef47ef4af539/jbacter00039-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b36/197032/ef47ef4af539/jbacter00039-0343-a.jpg

相似文献

1
Analysis of the dual regulatory mechanisms controlling expression of the vegetative catalase gene of Bacillus subtilis.枯草芽孢杆菌营养型过氧化氢酶基因表达的双重调控机制分析。
J Bacteriol. 1994 Nov;176(21):6744-8. doi: 10.1128/jb.176.21.6744-6748.1994.
2
The katX gene, which codes for the catalase in spores of Bacillus subtilis, is a forespore-specific gene controlled by sigmaF, and KatX is essential for hydrogen peroxide resistance of the germinating spore.katX基因编码枯草芽孢杆菌孢子中的过氧化氢酶，是一个受σF控制的前芽孢特异性基因，KatX对于萌发孢子的过氧化氢抗性至关重要。
J Bacteriol. 1998 Apr;180(8):2057-62. doi: 10.1128/JB.180.8.2057-2062.1998.
3
Coordinate regulation of Bacillus subtilis peroxide stress genes by hydrogen peroxide and metal ions.过氧化氢和金属离子对枯草芽孢杆菌过氧化物应激基因的协同调控
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8190-4. doi: 10.1073/pnas.92.18.8190.
4
Cloning, nucleotide sequence, and regulation of katE encoding a sigma B-dependent catalase in Bacillus subtilis.枯草芽孢杆菌中编码σB依赖性过氧化氢酶的katE的克隆、核苷酸序列及调控
J Bacteriol. 1995 Oct;177(19):5598-605. doi: 10.1128/jb.177.19.5598-5605.1995.
5
Mutation of the Bacillus subtilis alkyl hydroperoxide reductase (ahpCF) operon reveals compensatory interactions among hydrogen peroxide stress genes.枯草芽孢杆菌烷基过氧化氢还原酶（ahpCF）操纵子的突变揭示了过氧化氢应激基因之间的补偿性相互作用。
J Bacteriol. 1996 Nov;178(22):6579-86. doi: 10.1128/jb.178.22.6579-6586.1996.
6
The isolation, cloning and identification of a vegetative catalase gene from Bacillus subtilis.
Gene. 1991 Dec 20;109(1):31-7. doi: 10.1016/0378-1119(91)90585-y.
7
Expression in Bacillus subtilis of the Bacillus thuringiensis cryIIIA toxin gene is not dependent on a sporulation-specific sigma factor and is increased in a spo0A mutant.苏云金芽孢杆菌cryIIIA毒素基因在枯草芽孢杆菌中的表达不依赖于芽孢形成特异性σ因子，且在spo0A突变体中表达增加。
J Bacteriol. 1994 Aug;176(15):4734-41. doi: 10.1128/jb.176.15.4734-4741.1994.
8
Modulation of Bacillus subtilis catabolite repression by transition state regulatory protein AbrB.过渡态调节蛋白AbrB对枯草芽孢杆菌分解代谢物阻遏的调控
J Bacteriol. 1994 Apr;176(7):1903-12. doi: 10.1128/jb.176.7.1903-1912.1994.
9
Bacillus pumilus KatX2 confers enhanced hydrogen peroxide resistance to a Bacillus subtilis PkatA::katX2 mutant strain.短小芽孢杆菌KatX2赋予枯草芽孢杆菌PkatA::katX2突变株增强的过氧化氢抗性。
Microb Cell Fact. 2017 Apr 26;16(1):72. doi: 10.1186/s12934-017-0684-y.
10
Phosphate limitation induces catalase expression in Sinorhizobium meliloti, Pseudomonas aeruginosa and Agrobacterium tumefaciens.磷酸盐限制可诱导苜蓿中华根瘤菌、铜绿假单胞菌和根癌农杆菌中过氧化氢酶的表达。
Mol Microbiol. 2005 Nov;58(3):877-94. doi: 10.1111/j.1365-2958.2005.04874.x.

引用本文的文献

1
Crystal structure and biochemical analysis suggest that YjoB ATPase is a putative substrate-specific molecular chaperone.晶体结构和生化分析表明，YjoB ATP 酶是一种假定的底物特异性分子伴侣。
Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2207856119. doi: 10.1073/pnas.2207856119. Epub 2022 Oct 3.
2
Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide.过氧化氢调节感觉感知，使秀丽隐杆线虫能够找到既能提供食物又能免受过氧化氢伤害的栖息地。
PLoS Pathog. 2021 Dec 23;17(12):e1010112. doi: 10.1371/journal.ppat.1010112. eCollection 2021 Dec.
3

本文引用的文献

1
Heterogeneity of the principal sigma factor in Escherichia coli: the rpoS gene product, sigma 38, is a second principal sigma factor of RNA polymerase in stationary-phase Escherichia coli.大肠杆菌中主要σ因子的异质性：rpoS基因产物σ38是静止期大肠杆菌中RNA聚合酶的第二个主要σ因子。
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3511-5. doi: 10.1073/pnas.90.8.3511.
2
Purification of an SOS repressor from Bacillus subtilis.从枯草芽孢杆菌中纯化SOS阻遏蛋白。
J Bacteriol. 1993 Nov;175(21):6842-9. doi: 10.1128/jb.175.21.6842-6849.1993.
3
Isolation and characterization of a hydrogen peroxide resistant mutant of Bacillus subtilis.
The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress.
致病性钩端螺旋体对过氧化物的转录反应揭示了新的防御机制，以应对与感染相关的氧化应激。
PLoS Pathog. 2020 Oct 6;16(10):e1008904. doi: 10.1371/journal.ppat.1008904. eCollection 2020 Oct.
4
The K-State Promotes Stationary-Phase Mutagenesis via Oxidative Damage.K -State 通过氧化损伤促进静止期诱变。
Genes (Basel). 2020 Feb 11;11(2):190. doi: 10.3390/genes11020190.
5
AhpA is a peroxidase expressed during biofilm formation in Bacillus subtilis.AhpA是一种在枯草芽孢杆菌生物膜形成过程中表达的过氧化物酶。
Microbiologyopen. 2017 Feb;6(1). doi: 10.1002/mbo3.403. Epub 2016 Sep 28.
6
Why do bacteria use so many enzymes to scavenge hydrogen peroxide?为什么细菌要用这么多酶来清除过氧化氢？
Arch Biochem Biophys. 2012 Sep 15;525(2):145-60. doi: 10.1016/j.abb.2012.04.014. Epub 2012 May 16.
7
Carbohydrate-active enzymes from pigmented Bacilli: a genomic approach to assess carbohydrate utilization and degradation.有色芽孢杆菌中的碳水化合物活性酶：评估碳水化合物利用和降解的基因组方法。
BMC Microbiol. 2011 Sep 5;11:198. doi: 10.1186/1471-2180-11-198.
8
Artesunate potentiates antibiotics by inactivating heme-harbouring bacterial nitric oxide synthase and catalase.青蒿琥酯通过使携带血红素的细菌一氧化氮合酶和过氧化氢酶失活来增强抗生素的作用。
BMC Res Notes. 2011 Jun 30;4:223. doi: 10.1186/1756-0500-4-223.
9
Bacillus subtilis Vegetative Catalase Is an Extracellular Enzyme.枯草芽孢杆菌营养期过氧化氢酶是一种细胞外酶。
Appl Environ Microbiol. 1995 Dec;61(12):4471-3. doi: 10.1128/aem.61.12.4471-4473.1995.
10
The ytkD (mutTA) gene of Bacillus subtilis encodes a functional antimutator 8-Oxo-(dGTP/GTP)ase and is under dual control of sigma A and sigma F RNA polymerases.枯草芽孢杆菌的ytkD（mutTA）基因编码一种功能性抗突变8-氧代-（dGTP/GTP）酶，并且受σA和σF RNA聚合酶的双重调控。
J Bacteriol. 2004 Feb;186(4):1050-9. doi: 10.1128/JB.186.4.1050-1059.2004.
枯草芽孢杆菌过氧化氢抗性突变体的分离与鉴定
Microbiology (Reading). 1994 Feb;140 ( Pt 2):297-304. doi: 10.1099/13500872-140-2-297.
4
Elucidation of regulatory elements that control damage induction and competence induction of the Bacillus subtilis SOS system.枯草芽孢杆菌SOS系统中控制损伤诱导和感受态诱导的调控元件的阐明。
J Bacteriol. 1993 Sep;175(18):5907-15. doi: 10.1128/jb.175.18.5907-5915.1993.
5
Properties of Bacillus subtilis 168 derivatives freed of their natural prophages.枯草芽孢杆菌168衍生物去除其天然原噬菌体后的特性
Gene. 1980 Dec;12(1-2):155-9. doi: 10.1016/0378-1119(80)90026-8.
6
Inducible repair of oxidative DNA damage in Escherichia coli.大肠杆菌中氧化性DNA损伤的可诱导修复
Nature. 1983;304(5925):466-8. doi: 10.1038/304466a0.
7
Isolation of catalase-deficient Escherichia coli mutants and genetic mapping of katE, a locus that affects catalase activity.过氧化氢酶缺陷型大肠杆菌突变体的分离以及影响过氧化氢酶活性的基因座katE的遗传定位。
J Bacteriol. 1984 Feb;157(2):622-6. doi: 10.1128/jb.157.2.622-626.1984.
8
Genetic mapping of katF, a locus that with katE affects the synthesis of a second catalase species in Escherichia coli.katF的基因定位，katF是一个与katE共同影响大肠杆菌中第二种过氧化氢酶合成的基因座。
J Bacteriol. 1984 Nov;160(2):668-75. doi: 10.1128/jb.160.2.668-675.1984.
9
DNA-damage-inducible (din) loci are transcriptionally activated in competent Bacillus subtilis.DNA损伤诱导（din）基因座在感受态枯草芽孢杆菌中被转录激活。
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6201-5. doi: 10.1073/pnas.82.18.6201.
10
Catalases HPI and HPII in Escherichia coli are induced independently.大肠杆菌中的过氧化氢酶HPI和HPII是独立诱导产生的。
Arch Biochem Biophys. 1985 Nov 15;243(1):144-9. doi: 10.1016/0003-9861(85)90782-9.