• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
SPE1 and SPE2: two essential genes in the biosynthesis of polyamines that modulate +1 ribosomal frameshifting in Saccharomyces cerevisiae.SPE1和SPE2：酿酒酵母中多胺生物合成过程中的两个关键基因，它们可调节+1核糖体移码。
J Bacteriol. 1994 Nov;176(22):7126-8. doi: 10.1128/jb.176.22.7126-7128.1994.
2
The presence of an active S-adenosylmethionine decarboxylase gene increases the growth defect observed in Saccharomyces cerevisiae mutants unable to synthesize putrescine, spermidine, and spermine.活跃的S-腺苷甲硫氨酸脱羧酶基因的存在会加剧在无法合成腐胺、亚精胺和精胺的酿酒酵母突变体中观察到的生长缺陷。
J Bacteriol. 1994 Oct;176(20):6407-9. doi: 10.1128/jb.176.20.6407-6409.1994.
3
Spermidine deficiency increases +1 ribosomal frameshifting efficiency and inhibits Ty1 retrotransposition in Saccharomyces cerevisiae.亚精胺缺乏会提高酿酒酵母中的 +1 核糖体移码效率并抑制 Ty1 逆转录转座。
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):172-6. doi: 10.1073/pnas.91.1.172.
4
Translational recoding as a feedback controller: systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift.翻译后文本：作为反馈控制器的翻译重编码：系统方法揭示多胺对反义酶核糖体移码的特异性影响。
Nucleic Acids Res. 2011 Jun;39(11):4587-97. doi: 10.1093/nar/gkq1349. Epub 2011 Feb 7.
5
The biochemistry, genetics, and regulation of polyamine biosynthesis in Saccharomyces cerevisiae.酿酒酵母中多胺生物合成的生物化学、遗传学及调控
Fed Proc. 1982 Dec;41(14):3084-8.
6
Mutants of Saccharomyces cerevisiae deficient in polyamine biosynthesis: studies on the regulation of ornithine decarboxylase.缺乏多胺生物合成的酿酒酵母突变体：鸟氨酸脱羧酶调控的研究
Med Biol. 1981 Dec;59(5-6):272-8.
7
The Deficiency of Hypusinated eIF5A Decreases the Putrescine/Spermidine Ratio and Inhibits +1 Programmed Ribosomal Frameshifting during the Translation of Ty1 Retrotransposon in .eIF5A Hypusination 缺陷降低腐胺/精胺比并抑制 Ty1 逆转座子翻译中的 +1 核糖体移码
Int J Mol Sci. 2024 Feb 1;25(3):1766. doi: 10.3390/ijms25031766.
8
A new model for disruption of the ornithine decarboxylase gene, SPE1, in Saccharomyces cerevisiae exhibits growth arrest and genetic instability at the MAT locus.一种用于破坏酿酒酵母中鸟氨酸脱羧酶基因SPE1的新模型，在MAT基因座表现出生长停滞和遗传不稳定性。
Biochem J. 1995 Nov 15;312 ( Pt 1)(Pt 1):83-90. doi: 10.1042/bj3120083.
9
Polyamine metabolism and growth of neurospora strains lacking Cis-acting control sites in the ornithine decarboxylase gene.鸟氨酸脱羧酶基因中缺乏顺式作用控制位点的粗糙脉孢菌菌株的多胺代谢与生长
Arch Biochem Biophys. 1994 Nov 15;315(1):153-60. doi: 10.1006/abbi.1994.1484.
10
A rare tRNA-Arg(CCU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae.一种调控Ty1元件核糖体移码的罕见tRNA-Arg(CCU)对酿酒酵母中的Ty1逆转录转座至关重要。
Genetics. 1993 Oct;135(2):309-20. doi: 10.1093/genetics/135.2.309.

引用本文的文献

1
Biological Significance and Therapeutic Promise of Programmed Ribosomal Frameshifting.程序性核糖体移码的生物学意义与治疗前景
Int J Mol Sci. 2025 Feb 3;26(3):1294. doi: 10.3390/ijms26031294.
2
The Deficiency of Hypusinated eIF5A Decreases the Putrescine/Spermidine Ratio and Inhibits +1 Programmed Ribosomal Frameshifting during the Translation of Ty1 Retrotransposon in .eIF5A Hypusination 缺陷降低腐胺/精胺比并抑制 Ty1 逆转座子翻译中的 +1 核糖体移码
Int J Mol Sci. 2024 Feb 1;25(3):1766. doi: 10.3390/ijms25031766.
3
Improved production of Taxol precursors in S. cerevisiae using combinatorial in silico design and metabolic engineering.利用组合式计算机辅助设计和代谢工程提高酿酒酵母中紫杉醇前体的产量。
Microb Cell Fact. 2023 Nov 29;22(1):243. doi: 10.1186/s12934-023-02251-7.
4
Introduction to the Thematic Minireview Series: Sixty plus years of polyamine research.专题综述系列介绍：多胺研究六十余年。
J Biol Chem. 2018 Nov 30;293(48):18681-18692. doi: 10.1074/jbc.TM118.006291. Epub 2018 Oct 30.
5
Roles of polyamines in translation.多胺在翻译中的作用。
J Biol Chem. 2018 Nov 30;293(48):18719-18729. doi: 10.1074/jbc.TM118.003338. Epub 2018 Oct 15.
6
Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.核糖体移码和转录滑动：从基因隐写术和密码学到偶然用途。
Nucleic Acids Res. 2016 Sep 6;44(15):7007-78. doi: 10.1093/nar/gkw530. Epub 2016 Jul 19.
7
A Nascent Peptide Signal Responsive to Endogenous Levels of Polyamines Acts to Stimulate Regulatory Frameshifting on Antizyme mRNA.一种对多胺内源性水平有反应的新生肽信号，可刺激抗酶mRNA上的调控移码。
J Biol Chem. 2015 Jul 17;290(29):17863-17878. doi: 10.1074/jbc.M115.647065. Epub 2015 May 21.
8
The Ty1 LTR-retrotransposon of budding yeast, .芽殖酵母的Ty1长末端重复逆转座子，. （原文似乎不完整）
Microbiol Spectr. 2015 Apr 1;3(2):1-35. doi: 10.1128/microbiolspec.MDNA3-0053-2014.
9
Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization.果蝇 TAP/p32 是一种核心组蛋白伴侣，它在受精过程中与 NAP-1、NLP 和核磷蛋白一起参与精子染色质重塑。
Genes Dev. 2014 Sep 15;28(18):2027-40. doi: 10.1101/gad.248583.114.
10
The first step in the biosynthesis of cocaine in Erythroxylum coca: the characterization of arginine and ornithine decarboxylases.可卡因生物合成过程中的第一步：精氨酸和鸟氨酸脱羧酶的特性。
Plant Mol Biol. 2012 Apr;78(6):599-615. doi: 10.1007/s11103-012-9886-1. Epub 2012 Feb 7.

本文引用的文献

1
Alternative readings of the genetic code.遗传密码的其他解读方式。
Cell. 1993 Aug 27;74(4):591-6. doi: 10.1016/0092-8674(93)90507-m.
2
Spermidine deficiency increases +1 ribosomal frameshifting efficiency and inhibits Ty1 retrotransposition in Saccharomyces cerevisiae.亚精胺缺乏会提高酿酒酵母中的 +1 核糖体移码效率并抑制 Ty1 逆转录转座。
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):172-6. doi: 10.1073/pnas.91.1.172.
3
A novel programed frameshift expresses the POL3 gene of retrotransposon Ty3 of yeast: frameshifting without tRNA slippage.一种新型的程序性移码表达酵母逆转录转座子Ty3的POL3基因：无tRNA滑动的移码。
Cell. 1993 Jul 16;74(1):93-103. doi: 10.1016/0092-8674(93)90297-4.
4
A rare tRNA-Arg(CCU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae.一种调控Ty1元件核糖体移码的罕见tRNA-Arg(CCU)对酿酒酵母中的Ty1逆转录转座至关重要。
Genetics. 1993 Oct;135(2):309-20. doi: 10.1093/genetics/135.2.309.
5
Polyamines regulate the expression of ornithine decarboxylase antizyme in vitro by inducing ribosomal frame-shifting.多胺通过诱导核糖体移码在体外调节鸟氨酸脱羧酶抗酶的表达。
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3959-63. doi: 10.1073/pnas.91.9.3959.
6
Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies.阅读框的翻译维持：酿酒酵母中-1核糖体移码效率改变的突变体
Genetics. 1994 Jan;136(1):75-86. doi: 10.1093/genetics/136.1.75.
7
Ribosome frameshifting at hungry codons: sequence rules, directional specificity and possible relationship to mobile element behaviour.饥饿密码子处的核糖体移码：序列规则、方向特异性以及与移动元件行为的可能关系。
Biochem Soc Trans. 1993 Nov;21(4):817-21. doi: 10.1042/bst0210817.
8
Ornithine decarboxylase from Saccharomyces cerevisiae. Purification, properties, and regulation of activity.来自酿酒酵母的鸟氨酸脱羧酶。纯化、性质及活性调节
J Biol Chem. 1981 Dec 10;256(23):12156-63.
9
Localization of polyamine enhancement of protein synthesis to subcellular components of Escherichia coli and Pseudomonas sp. strain Kim.多胺对蛋白质合成的促进作用在大肠杆菌和假单胞菌属金氏菌株亚细胞组分中的定位
J Bacteriol. 1983 Jan;153(1):326-34. doi: 10.1128/jb.153.1.326-334.1983.
10
Differential binding of streptomycin to ribosomes of polyamine-deficient bacteria grown in the absence and presence of putrescine.
FEBS Lett. 1982 Jun 7;142(2):275-9. doi: 10.1016/0014-5793(82)80151-8.

SPE1和SPE2：酿酒酵母中多胺生物合成过程中的两个关键基因，它们可调节+1核糖体移码。

SPE1 and SPE2: two essential genes in the biosynthesis of polyamines that modulate +1 ribosomal frameshifting in Saccharomyces cerevisiae.

作者信息

Balasundaram D, Dinman J D, Tabor C W, Tabor H

机构信息

Laboratory of Biochemical Pharmacology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892-0830.

出版信息

J Bacteriol. 1994 Nov;176(22):7126-8. doi: 10.1128/jb.176.22.7126-7128.1994.

DOI:10.1128/jb.176.22.7126-7128.1994
PMID:7961484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC197094/
Abstract

We previously showed that a mutant of Saccharomyces cerevisiae, which cannot make spermidine as a result of a deletion in the SPE2 gene (spe2 delta), exhibits a marked elevation in +1 ribosomal frameshifting efficiency in response to the Ty1 frameshift sequence, CUU AGG C. In the present study, we found that spermidine deprivation alone does not result in increased +1 ribosomal frameshifting efficiency. The high level of +1 ribosomal frameshifting efficiency in spe2 delta cells is the result of the combined effects of both spermidine deprivation and the large increase in the level of intracellular putrescine resulting from the derepression of the gene for ornithine decarboxylase (SPE1) in spermidine-deficient strains.

摘要

我们之前发现，由于SPE2基因缺失（spe2Δ）而无法合成亚精胺的酿酒酵母突变体，在响应Ty1移码序列CUU AGG C时，+1核糖体移码效率显著提高。在本研究中，我们发现单独的亚精胺缺乏并不会导致+1核糖体移码效率增加。spe2Δ细胞中高水平的+1核糖体移码效率是亚精胺缺乏和亚精胺缺陷菌株中鸟氨酸脱羧酶基因（SPE1）去抑制导致细胞内腐胺水平大幅增加共同作用的结果。