O'Rourke D A, Wurtman J J, Wurtman R J, Tsay R, Gleason R, Baer L, Jenike M A
Clinical Research Center, Massachusetts Institute of Technology, Cambridge.
J Clin Psychiatry. 1994 Oct;55(10):445-7.
Appetitive symptoms, particularly carbohydrate craving, have been shown to occur in patients whose conditions responded to treatment with drugs that enhance serotonin-mediated neurotransmission. This suggested that patients with obsessive compulsive disorder (OCD) who also frequently respond to serotonergic drugs also might have similar distributions of appetitive and eating patterns.
A survey study of 170 OCD patients and 920 controls was conducted using a questionnaire that inquired about snacking behavior, including food preference, mood changes after eating, and previous diagnosis of eating disorders. The frequency responses in the two groups were tested for statistical significance.
Significant differences were found between the OCD and control groups with respect to the reported incidence of eating disorders, snacking patterns, and mood response to food.
This finding of different snacking patterns in OCD mirrors that found in other disorders that have been shown to be responsive to serotonergic drugs. The high incidence of carbohydrate snacking among OCD patients compared with the control group provides additional evidence that brain serotonin may be involved in this disorder.
已表明，在病情对增强5-羟色胺介导的神经传递的药物治疗有反应的患者中会出现食欲症状，尤其是对碳水化合物的渴望。这表明，同样经常对5-羟色胺能药物有反应的强迫症（OCD）患者也可能有类似的食欲和饮食模式分布。
使用一份问卷对170名强迫症患者和920名对照者进行了一项调查研究，该问卷询问了零食行为，包括食物偏好、进食后的情绪变化以及既往饮食失调诊断情况。对两组的频率反应进行统计学显著性检验。
在强迫症患者组和对照组之间，在报告的饮食失调发生率、零食模式以及对食物的情绪反应方面发现了显著差异。
强迫症患者中不同零食模式的这一发现与其他已表明对5-羟色胺能药物有反应的疾病中的发现相似。与对照组相比，强迫症患者中碳水化合物零食的高发生率提供了额外证据，表明大脑5-羟色胺可能与该疾病有关。
