抗抑郁药在突触处的药理学：聚焦于新型化合物。
The pharmacology of antidepressants at the synapse: focus on newer compounds.
作者信息
Richelson E
机构信息
Department of Research, Mayo Clinic Jacksonville, Fla. 32224.
出版信息
J Clin Psychiatry. 1994 Sep;55 Suppl A:34-9; discussion 40-1, 98-100.
PMID:7961541
Abstract
This paper reviews the in vitro effects of antidepressants on blockade of uptake of norepinephrine, serotonin, and dopamine at the synapse (rat synaptosomal preparations), as well as blockade of histamine H1, muscarinic, alpha 1-adrenergic, and dopamine D2 receptors in human brain tissue. The potency of an antidepressant at this blockade is predictive of the likelihood of its causing certain side effects and drug-drug interactions.
摘要
本文综述了抗抑郁药对突触处去甲肾上腺素、5-羟色胺和多巴胺摄取的体外阻断作用（大鼠突触体标本），以及对人脑组织中组胺H1、毒蕈碱、α1-肾上腺素能和多巴胺D2受体的阻断作用。抗抑郁药在这种阻断作用上的效力可预测其引起某些副作用和药物相互作用的可能性。
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