Schmidt P J, Purdy R H, Moore P H, Paul S M, Rubinow D R
Section on Behavioral Endocrinology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892.
J Clin Endocrinol Metab. 1994 Nov;79(5):1256-60. doi: 10.1210/jcem.79.5.7962316.
The levels of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and the epimeric 3 alpha-hydroxy-5 beta-pregnan-20-one (pregnanolone) were studied in women with prospectively confirmed premenstrual syndrome (n = 15) and in a group of asymptomatic control women (n = 12) during the luteal phase of the menstrual cycle. Single late luteal phase plasma samples were selected to make comparisons of plasma hormone levels between patients and controls in the following measures: allopregnanolone, pregnanolone, the ratio of allopregnanolone to pregnanolone, the ratio for each of these anxiolytic steroids to the parent compound progesterone, and the ratio of the sum of allopregnanolone and pregnanolone to progesterone. Differences in these measures were compared by analysis of variance. Additionally, correlations were performed among the various hormone measures and between the hormone measures and the symptom self-ratings. Analysis of variance showed no significant between group differences in the plasma levels of allopregnanolone, pregnanolone, and progesterone. Plasma levels of both allopregnanolone and pregnanolone were correlated with plasma progesterone levels. However, there were no significant correlations between the severity of mood and behavioral symptoms and plasma levels of progesterone, allopregnanolone, and pregnanolone. These data suggest that symptoms of premenstrual syndrome are not associated with a simple deficiency state of either progesterone or its anxiolytic steroid metabolites.
在月经周期的黄体期，对前瞻性确诊为经前综合征的女性（n = 15）和一组无症状对照女性（n = 12）的3α-羟基-5α-孕烷-20-酮（别孕烯醇酮）及差向异构体3α-羟基-5β-孕烷-20-酮（孕烯醇酮）水平进行了研究。选取黄体期末期的单次血浆样本，以比较患者和对照在以下指标中的血浆激素水平：别孕烯醇酮、孕烯醇酮、别孕烯醇酮与孕烯醇酮的比值、这些抗焦虑类固醇与母体化合物孕酮的比值，以及别孕烯醇酮和孕烯醇酮之和与孕酮的比值。通过方差分析比较这些指标的差异。此外，对各种激素指标之间以及激素指标与症状自评之间进行了相关性分析。方差分析显示，别孕烯醇酮、孕烯醇酮和孕酮的血浆水平在组间无显著差异。别孕烯醇酮和孕烯醇酮的血浆水平均与血浆孕酮水平相关。然而，情绪和行为症状的严重程度与孕酮、别孕烯醇酮和孕烯醇酮的血浆水平之间无显著相关性。这些数据表明，经前综合征的症状与孕酮或其抗焦虑类固醇代谢产物的单纯缺乏状态无关。
