Bicíková M, Dibbelt L, Hill M, Hampl R, Stárka L
Institute of Endocrinology, Praha, Czech Republic.
Horm Metab Res. 1998 Apr;30(4):227-30. doi: 10.1055/s-2007-978871.
5Alpha-reduced metabolites of progesterone, especially 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) are now listed to neurosteroids. Their anesthetic properties can be explained by their allosteric interaction with GABA(A) receptors. A woman's organism is provided with an abundance of progesterone during the luteal phase of the menstrual cycle and its level falls down sharply with the first day of menses. The level of allopregnanolone follows that of progesterone. Many women suffer from so called premenstrual syndrome (PMS) during the luteal phase. In this study we have determined allopregnanolone and progesterone levels and their ratios in order to assess the over-all activity of C21-steroid 5alpha-reductase in these patients and in controls. Significantly lower levels of both progesterone and allopregnanolone than in controls have been found in PMS patients in the follicular phase only.
孕酮的5α-还原代谢产物，尤其是3α-羟基-5α-孕烷-20-酮（别孕烯醇酮）现在被列为神经甾体。它们的麻醉特性可以通过其与GABA(A)受体的变构相互作用来解释。女性机体在月经周期的黄体期会分泌大量孕酮，而在月经第一天其水平会急剧下降。别孕烯醇酮的水平与孕酮的水平变化一致。许多女性在黄体期会出现所谓的经前综合征（PMS）。在本研究中，我们测定了别孕烯醇酮和孕酮的水平及其比值，以评估这些患者和对照组中C21-甾体5α-还原酶的总体活性。仅在卵泡期的PMS患者中发现，其孕酮和别孕烯醇酮水平均显著低于对照组。
