Edwards R G
Churchill College, Cambridge and London Women's Clinic, UK.
Hum Reprod. 1994 Jun;9(6):985-95. doi: 10.1093/oxfordjournals.humrep.a138673.
The factors involved in post-fertilization events leading to implantation in mammals are discussed with special reference to potential forms of interception. The stages of embryonic growth until implantation are considered initially. The growth and differentiation of the uterine endometrium is then described, followed by the events occurring during the apposition and invasion of the implanting embryo. Several potential approaches to new forms of interception are considered, and the advantages and disadvantages of each of them are evaluated. Among them, new vaccines against the zona pellucida, inactivation of the secretions of the blastocyst, hatching, the activity of pinopodes, and the endometrial proteins produced in the secretory phase seem to offer various and varied targets. Some existing methods of fertility regulation may act by affecting these stages of development, e.g. RU486 may interfere with pinopod function. Various physiological and embryonic consequences of interfering with these stages of pregnancy are discussed.
本文特别参考了潜在的阻断形式，讨论了哺乳动物受精后导致着床的相关因素。首先考虑了胚胎生长直至着床的各个阶段。接着描述了子宫内膜的生长和分化，随后阐述了着床胚胎附着和侵入过程中发生的事件。文中考虑了几种新型阻断方法的潜在途径，并评估了每种方法的优缺点。其中，针对透明带的新型疫苗、胚泡分泌物的失活、孵化、微绒毛的活性以及分泌期产生的子宫内膜蛋白似乎提供了各种各样的靶点。一些现有的生育调节方法可能通过影响这些发育阶段起作用，例如RU486可能会干扰微绒毛功能。本文还讨论了干扰这些妊娠阶段所产生的各种生理和胚胎学后果。
