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白血病抑制因子：在胚胎植入和非激素避孕中的作用。

Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception.

作者信息

Salleh Naguib, Giribabu Nelli

机构信息

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

ScientificWorldJournal. 2014;2014:201514. doi: 10.1155/2014/201514. Epub 2014 Jul 24.

DOI:10.1155/2014/201514
PMID:25152902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4131495/
Abstract

Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception.

摘要

白血病抑制因子（LIF）在胚胎着床过程中发挥着不可或缺的作用。LIF产生异常与着床失败有关。LIF在着床前及着床过程中调节多个过程，如子宫转化为接受态、蜕膜化、囊胚生长发育、胚胎与子宫内膜相互作用、滋养层细胞侵袭及免疫调节。由于其关键作用，LIF已成为非激素避孕的靶点。在本综述中，我们总结了关于LIF在着床中的作用及其在避孕中的作用的最新信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa13/4131495/0e41b2d448f4/TSWJ2014-201514.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa13/4131495/0e41b2d448f4/TSWJ2014-201514.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa13/4131495/0e41b2d448f4/TSWJ2014-201514.001.jpg

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