Tournaye H, Van Steirteghem A C, Devroey P
Centre for Reproductive Medicine, Academisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
Hum Reprod. 1994 Jun;9(6):996-1000. doi: 10.1093/oxfordjournals.humrep.a138674.
Since the use of pentoxifylline has received much recent attention for its role in the treatment of male-factor infertility by in-vitro fertilization, there is now an increasing interest in its oral use. Therefore, results reported in the literature on the treatment of idiopathic male-factor infertility by oral administration of pentoxifylline were summarized and reviewed. None of the reports presented a valid rationale for the systematic use of pentoxifylline and the reported results were found to be conflicting. Because of poor study design or low statistical power, the published data did not support a beneficial role of the systemic use of pentoxifylline in idiopathic male-factor infertility. Prospective, double blind trials dealing with fecundity as the major outcome measure may provide the information needed.
由于己酮可可碱在体外受精治疗男性因素不孕症中的作用最近备受关注，其口服应用的兴趣也日益增加。因此，对文献中关于口服己酮可可碱治疗特发性男性因素不孕症的结果进行了总结和综述。没有一份报告提出系统使用己酮可可碱的有效理论依据，且所报告的结果相互矛盾。由于研究设计不佳或统计效力低，已发表的数据不支持全身使用己酮可可碱对特发性男性因素不孕症有有益作用。以生育力作为主要结局指标的前瞻性双盲试验可能会提供所需信息。
