己酮可可碱在体外及口服治疗后均可刺激人类精子活力。
Pentoxifylline stimulates human sperm motility both in vitro and after oral therapy.
作者信息
Shen M R, Chiang P H, Yang R C, Hong C Y, Chen S S
机构信息
Department of Neurology, Kaoshsiung Medical College, Taiwan, R.O.C.
出版信息
Br J Clin Pharmacol. 1991 Jun;31(6):711-4. doi: 10.1111/j.1365-2125.1991.tb05600.x.
Abstract
Pentoxifylline is a haemorrheologic agent often used in the treatment of peripheral vascular disorders. In this study, we measured sperm motility with a trans-membrane migration method and investigated the effect of this drug in the treatment of male infertility. We found that pentoxifylline increased motility of ejaculated spermatozoa in vitro from both normal and asthenozoospermic samples. After giving pentoxifylline to patients with asthenozoospermia for 3 months, sperm motility significantly increased, but sperm concentration did not increase. From the above results, it can be concluded that pentoxifylline is a useful drug in the treatment of normogonadotropic asthenozoospermia.
摘要
己酮可可碱是一种常用于治疗外周血管疾病的血液流变学药物。在本研究中，我们采用跨膜迁移法测量精子活力，并研究了该药物在治疗男性不育症中的作用。我们发现，己酮可可碱可提高正常和弱精子症样本体外射精精子的活力。给弱精子症患者服用己酮可可碱3个月后，精子活力显著提高，但精子浓度未增加。从上述结果可以得出结论，己酮可可碱是治疗促性腺激素正常的弱精子症的有效药物。
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