Bernstein E F, Harisiadis L, Salomon G D, Harrington F, Mitchell J B, Uitto J, Glatstein E, Russo A
Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541.
J Dermatol Surg Oncol. 1994 Nov;20(11):757-60. doi: 10.1111/j.1524-4725.1994.tb03200.x.
Ionizing radiation is frequently used for the treatment of malignancy. Sequelae of therapeutic radiation frequently present clinical problems in the form of poor wound healing and easy injury of treated tissue in response to mild trauma.
We describe a radiation-impaired wound healing model in guinea pigs, developed to determine the effect of cutaneous irradiation on wound contraction.
Guinea pigs were anesthetized and a flap of skin was isolated and treated with x-rays to 18 Gy. Circular wounds of identical size were made in irradiated and control skin, and average wound size was recorded.
Our results demonstrate that a statistically significant wound healing deficit is produced in open wounds by surface irradiation of skin.
Radiation of skin results in slower healing of open wounds, and provides an in vivo system for evaluation of topical dressings and growth factors in radiation-impaired wounds.
电离辐射常用于恶性肿瘤的治疗。治疗性辐射的后遗症常常以伤口愈合不良以及治疗组织在受到轻度创伤时易受伤的形式出现临床问题。
我们描述了一种豚鼠辐射损伤伤口愈合模型，该模型用于确定皮肤照射对伤口收缩的影响。
将豚鼠麻醉，分离一块皮瓣并用X射线照射至18 Gy。在照射皮肤和对照皮肤处制作相同大小的圆形伤口，并记录平均伤口大小。
我们的结果表明，皮肤表面照射会在开放性伤口中产生具有统计学意义的伤口愈合缺陷。
皮肤辐射会导致开放性伤口愈合减慢，并为评估辐射损伤伤口的局部敷料和生长因子提供了一个体内系统。
