Vandoren G, Van Baelen H, Verhoeven G, De Moor P
J Endocrinol. 1978 Jul;78(1):31-8. doi: 10.1677/joe.0.0780031.
Evidence is presented that the level of alpha 2u-globulin in the serum of male rats depends, at least in part, on neonatal androgens. After castration of adult animals the concentration of this protein falls but remains measurable, whereas in intact or ovariectomized female rats alpha 2u-globulin cannot be detected. Moreover, alpha 2u-globulin is found in adult male and female rats gonadectomized at birth and treated with a single injection of testosterone propionate immediately thereafter. The mechanism by which neonatal androgens increase the concentration of alpha 2u-globulin has been investigated. Transplantation of a supplementary pituitary gland under the renal capsule of male rats resulted in reduced levels of alpha 2u-globulin and increased levels of transcortin. The changes discussed here were observed only in those animals in which the transplant was functional and they were amplified or reversed by modulators of prolactin secretion such as oestrogens or bromocriptine respectively. The hypothesis is advanced that neonatal androgens stimulate the production of a hypothalamic inhibitory factor that controls the secretion of prolactin, or another hypophysial hormone subjected to similar neuroendocrine control. Measurements in gonadectomized animals and in rats receiving both oestradiol benzoate and bromocriptine indicate that, besides these pituitary-mediated effects, both oestrogens and androgens exert direct effects on the level of alpha 2u-globulin.
有证据表明，雄性大鼠血清中α2u球蛋白的水平至少部分取决于新生期雄激素。成年动物去势后，这种蛋白质的浓度下降，但仍可检测到，而在完整或去卵巢的雌性大鼠中则检测不到α2u球蛋白。此外，在出生时去势并随后立即单次注射丙酸睾酮的成年雄性和雌性大鼠中也发现了α2u球蛋白。已经研究了新生期雄激素增加α2u球蛋白浓度的机制。将一个额外的垂体移植到雄性大鼠的肾囊下，导致α2u球蛋白水平降低，皮质素结合蛋白水平升高。这里讨论的变化仅在移植功能正常的动物中观察到，并且分别被催乳素分泌调节剂如雌激素或溴隐亭放大或逆转。提出的假说是，新生期雄激素刺激下丘脑抑制因子的产生，该抑制因子控制催乳素或另一种受类似神经内分泌控制的垂体激素的分泌。对去势动物以及同时接受苯甲酸雌二醇和溴隐亭的大鼠的测量表明，除了这些垂体介导的作用外，雌激素和雄激素对α2u球蛋白水平都有直接影响。
