Widhalm K, Stargel W W, Burns T S, Tschanz C
Department of Pediatrics, University of Vienna, Austria.
J Am Coll Nutr. 1994 Aug;13(4):392-6. doi: 10.1080/07315724.1994.10718427.
The objective of this randomized, double-blind, two-way crossover study in healthy children was to evaluate whether microparticulated protein (MPP, Simplesse) fat substitute had any effects on various clinical and biochemical parameters when compared to super premium ice cream (approximately 16% butterfat).
Twenty-four children (12 males, 12 females), 7-10 years of age, received their normal diet plus two consecutive 7-day treatment regimens consisting of one serving (approximately 196 mL) per day of either ice cream or a frozen dessert made with MPP. Three-day food diaries, routine hematologies, clinical chemistries, urinalyses, fasting plasma lipids and amino acids, vital signs and adverse experiences were compared between treatments.
There were no clinically significant effects on any of the parameters following either treatment, although there were statistically significant increases in fasting plasma cholesterol and high-density lipoprotein cholesterol following ice cream when compared to MPP. There were no statistically significant differences between the two treatments in regard to macronutrient consumption. The only adverse experience related to treatment was one episode of vomiting following the ice cream. The children ingested more than five times the amount of MPP than that found in the 90th percentile of frozen dessert consumption by this age group. The protein intake (5.5 g/day) from MPP at this level of consumption would only modestly increase the total daily protein intake.
Children ingesting approximately 196 mL/day of frozen dessert made with MPP did not show any clinically significant changes in various clinical and biochemical parameters.
本项针对健康儿童的随机、双盲、双向交叉研究旨在评估与超级优质冰淇淋（约含16%乳脂）相比，微粒化蛋白质（MPP，Simplesse）脂肪替代品对各项临床和生化参数是否有影响。
24名7至10岁儿童（12名男性，12名女性）在正常饮食基础上，连续接受两个为期7天的治疗方案，每天食用一份（约196毫升）冰淇淋或用MPP制作的冷冻甜点。对两种治疗方式下的三日饮食日记、常规血液学检查、临床化学检查、尿液分析、空腹血脂和氨基酸、生命体征及不良经历进行比较。
两种治疗后，各项参数均未出现具有临床意义的影响，不过与MPP相比，食用冰淇淋后空腹血浆胆固醇和高密度脂蛋白胆固醇有统计学显著升高。两种治疗在常量营养素摄入方面无统计学显著差异。与治疗相关的唯一不良经历是食用冰淇淋后出现一次呕吐。儿童摄入的MPP量是该年龄组冷冻甜点摄入量第90百分位数的五倍多。在此摄入量水平下，来自MPP的蛋白质摄入量（5.5克/天）只会适度增加每日总蛋白质摄入量。
每日摄入约196毫升用MPP制作的冷冻甜点的儿童，在各项临床和生化参数上未出现任何具有临床意义的变化。
