van 't Wout J W, Herrmann W A, de Vries R A, Stricker B H
Department of Internal Medicine and Dermatology, Bronovo Hospital, The Hague, The Netherlands.
J Hepatol. 1994 Jul;21(1):115-7. doi: 10.1016/s0168-8278(94)80146-0.
We describe two cases of terbinafine-associated hepatic injury, in which a mixed cholestatic-hepatocellular type of hepatitis was present. In both cases extrahepatic cholestasis and viral hepatitis were excluded and involvement of other drugs was unlikely. In the first patient all abnormalities have disappeared, but in the second patient alkaline phosphatase, aminotransferase and gamma-glutamyl transferase levels have remained elevated (follow up 3 months after cessation of treatment with terbinafine). Most likely, the terbinafine-associated hepatic injury in these patients was caused by an idiosyncratic rather than a direct hepatotoxic reaction.
我们描述了两例与特比萘芬相关的肝损伤病例，均表现为胆汁淤积性和肝细胞性混合型肝炎。两例均排除了肝外胆汁淤积和病毒性肝炎，且不太可能涉及其他药物。第一例患者的所有异常均已消失，但第二例患者的碱性磷酸酶、氨基转移酶和γ-谷氨酰转移酶水平仍持续升高（在停用特比萘芬治疗3个月后随访）。很可能，这些患者中与特比萘芬相关的肝损伤是由特异质性反应而非直接肝毒性反应引起的。
