Boldewijn O Y, Ottervanger J P, Mostart C M, Janssens A R, Calame J, Jonkers G J
Afd. Inwendige Geneeskunde, Rijnlandziekenhuis, Leiderdorp.
Ned Tijdschr Geneeskd. 1996 Mar 23;140(12):669-72.
A 71-year-old woman was admitted to our hospital with jaundice after she had been using terbinafine for a few weeks. The liver function tests showed a mixed cholestatic-hepatocellular pattern. A liver biopsy revealed large amounts of intracellular bile pigment. Causes of the liver disorder other than the use of the aforementioned antimycotic drug were excluded. Ten months after cessation of the drug the patient had recovered completely. The Netherlands Inspectorate for Health Care received 20 reports of liver enzyme elevations due to terbinafine in 1991-1994.
一名71岁女性在使用特比萘芬几周后因黄疸入住我院。肝功能检查显示为胆汁淤积性和肝细胞性混合模式。肝活检发现大量细胞内胆汁色素。排除了使用上述抗真菌药物以外的肝脏疾病病因。停药十个月后，患者已完全康复。荷兰医疗保健检查局在1991年至1994年期间收到了20例因特比萘芬导致肝酶升高的报告。
