van der Geest R J, Morris K G, Cusma J T, Reiber J H
Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
Int J Card Imaging. 1994 Jun;10(2):95-102. doi: 10.1007/BF01137704.
Goal of this study was to compare the quantitative coronary arteriographic (QCA) results obtained with the Philips DCI/ACA analytical software package with those from postmortem casts in an animal experimental setting. Standard digital coronary arteriograms were obtained from 6 mongrel dogs. After the imaging procedure, the dogs were sacrificed and casts were made of the coronary trees by filling the vessels with a mixture of radio-opaque barium and silicone gel at a fixed pressure of 100 mmHg. Vessel diameters were measured from the digital arteriograms at a total of 118 selected locations with the ACA package. Thin slices were cut from the casts at these same measurement locations and the areas of the cross sections were obtained by manual tracing of the outline of each slice in an approximately 40 x magnified image. From these cross-sectional areas, cast diameters were derived using the formula for circular cross-sections. Cast diameters ranged in size from 0.69 to 3.30 mm. The systematic error between the measurements was found to be 0.058 mm; (p < 0.015) and the standard deviation of the signed difference 0.255 mm; the correlation coefficient was r = 0.91. The largest error sources are supposed to be the slight differences in the selection of identical positions in the X-ray images and on the casts, and the 'out-of-plane' magnification for a number of vessel locations. This postmortem study demonstrates that the diameters of coronary vessels can be measured from digital arteriograms with the DCI/ACA package with a high degree of accuracy and precision.
本研究的目的是在动物实验环境中，将使用飞利浦DCI/ACA分析软件包获得的定量冠状动脉造影（QCA）结果与死后铸型的结果进行比较。从6只杂种狗身上获取了标准数字冠状动脉造影图像。成像程序完成后，处死这些狗，并通过在100 mmHg的固定压力下用不透射线的钡和硅胶混合物填充血管，制作冠状动脉树的铸型。使用ACA软件包在总共118个选定位置从数字动脉造影图像上测量血管直径。在这些相同的测量位置从铸型上切下薄片，并通过在大约40倍放大的图像中手动描绘每个薄片的轮廓来获得横截面面积。根据这些横截面面积，使用圆形横截面公式得出铸型直径。铸型直径范围为0.69至3.30 mm。测量之间的系统误差为0.058 mm；（p < 0.015），符号差的标准差为0.255 mm；相关系数为r = 0.91。最大的误差来源应该是X射线图像和铸型上相同位置选择的细微差异，以及一些血管位置的“平面外”放大。这项死后研究表明，使用DCI/ACA软件包可以从数字动脉造影图像中高精度和高精确度地测量冠状动脉直径。
