Nagahara K, Wada Y
Department of Orthopaedic Surgery, School of Medicine Chiba University, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1994 Sep;68(9):784-9.
The purpose of this study was to carry out a histological evaluation of cryopreserved menisci used as allografts in monkeys. Menisci were evaluated histologically at one, three, six and at twelve months after transplantation. In the deep layer of the allografts, the number of cells and the amount of the extracellular matrix had decreased at three to six months after transplantation. After twelve months, the evaluation revealed that both the cell counts and the extracellular matrix had increased returning to nearly normal levels. However, the colour of the matrix stained with Masson's trichrome had changed to red. This change may correspond with the occurrence that of young newly-formed collagen. Since the articular cartilage showed minimal degenerative change, it is concluded that meniscal transplantation is useful and should be considered for meniscal injuries.
本研究的目的是对作为同种异体移植物用于猴子的冷冻保存半月板进行组织学评估。在移植后1个月、3个月、6个月和12个月对半月板进行组织学评估。在同种异体移植物的深层，移植后3至6个月细胞数量和细胞外基质数量减少。12个月后，评估显示细胞计数和细胞外基质均增加，恢复到几乎正常的水平。然而，用马森三色染色的基质颜色已变为红色。这种变化可能与年轻的新形成胶原蛋白的出现相对应。由于关节软骨显示出最小程度的退行性变化，得出的结论是半月板移植是有用的，对于半月板损伤应予以考虑。
